Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies
Abstract Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) in the substantia nigra, from MRI-based quantitative susceptibility mapping (QSM), is a p...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83593-z |
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| author | Oliver C. Kiersnowski Pietro Mattioli Lucia Argenti Laura Avanzino Francesco Calizzano Andrea Diociasi Laura Falcitano Chunlei Liu Mattia Losa Federico Massa Silvia Morbelli Beatrice Orso Elisa Pelosin Stefano Raffa Matteo Pardini Dario Arnaldi Luca Roccatagliata Mauro Costagli |
| author_facet | Oliver C. Kiersnowski Pietro Mattioli Lucia Argenti Laura Avanzino Francesco Calizzano Andrea Diociasi Laura Falcitano Chunlei Liu Mattia Losa Federico Massa Silvia Morbelli Beatrice Orso Elisa Pelosin Stefano Raffa Matteo Pardini Dario Arnaldi Luca Roccatagliata Mauro Costagli |
| author_sort | Oliver C. Kiersnowski |
| collection | DOAJ |
| description | Abstract Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) in the substantia nigra, from MRI-based quantitative susceptibility mapping (QSM), is a potential biomarker of nigrostriatal degeneration, however, QSM cannot disentangle paramagnetic (e.g. iron) and diamagnetic (e.g. myelin) sources. Using the susceptibility source-separation technique DECOMPOSE, paramagnetic component susceptibility (PCS) and diamagnetic component susceptibility (DCS) were studied in prodromal and overt alpha-synucleinopathies, and their relationships with DaT-SPECT specific binding ratio (SBR) and clinical scores. 78 participants were included (23 controls, 30 prodromal and 25 overt alpha-synucleinopathies). Prodromal patients were subdivided into groups with positive or negative DaT-SPECT (SBR Z-scores below or above -1, respectively). Correlations of putamen and caudate SBR Z-scores with PCS and DCS in the substantia nigra, putamen, and caudate were investigated. Increased PCS was observed in the substantia nigra of prodromal alpha-synucleinopathy patients with positive DaT-SPECT compared to controls and prodromal patients with negative DaT-SPECT. SBR Z-scores in the putamen correlated with increased PCS in the substantia nigra and reduced |DCS| in the putamen, which may reflect dopaminergic degeneration ascribable to iron accumulation and nigrostriatal neuron axonal loss, respectively. |
| format | Article |
| id | doaj-art-eaa49cf26d1c4b99946630c821bcc484 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-eaa49cf26d1c4b99946630c821bcc4842025-02-09T12:34:25ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-024-83593-zMagnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathiesOliver C. Kiersnowski0Pietro Mattioli1Lucia Argenti2Laura Avanzino3Francesco Calizzano4Andrea Diociasi5Laura Falcitano6Chunlei Liu7Mattia Losa8Federico Massa9Silvia Morbelli10Beatrice Orso11Elisa Pelosin12Stefano Raffa13Matteo Pardini14Dario Arnaldi15Luca Roccatagliata16Mauro Costagli17IRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of GenovaIRCCS Ospedale Policlinico San MartinoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of GenovaIRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoUniversity of California BerkeleyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of GenovaIRCCS Ospedale Policlinico San MartinoDepartment of Nuclear Medicine, University of TurinDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of GenovaIRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoIRCCS Ospedale Policlinico San MartinoAbstract Nigrostriatal dopaminergic degeneration in alpha-synucleinopathies is indirectly reflected by low dopamine transporter (DaT) uptake through [123I]FP-CIT-SPECT. Bulk magnetic susceptibility ( $$\chi$$ ) in the substantia nigra, from MRI-based quantitative susceptibility mapping (QSM), is a potential biomarker of nigrostriatal degeneration, however, QSM cannot disentangle paramagnetic (e.g. iron) and diamagnetic (e.g. myelin) sources. Using the susceptibility source-separation technique DECOMPOSE, paramagnetic component susceptibility (PCS) and diamagnetic component susceptibility (DCS) were studied in prodromal and overt alpha-synucleinopathies, and their relationships with DaT-SPECT specific binding ratio (SBR) and clinical scores. 78 participants were included (23 controls, 30 prodromal and 25 overt alpha-synucleinopathies). Prodromal patients were subdivided into groups with positive or negative DaT-SPECT (SBR Z-scores below or above -1, respectively). Correlations of putamen and caudate SBR Z-scores with PCS and DCS in the substantia nigra, putamen, and caudate were investigated. Increased PCS was observed in the substantia nigra of prodromal alpha-synucleinopathy patients with positive DaT-SPECT compared to controls and prodromal patients with negative DaT-SPECT. SBR Z-scores in the putamen correlated with increased PCS in the substantia nigra and reduced |DCS| in the putamen, which may reflect dopaminergic degeneration ascribable to iron accumulation and nigrostriatal neuron axonal loss, respectively.https://doi.org/10.1038/s41598-024-83593-zAlpha-synucleinopathiesQuantitative susceptibility mappingDECOMPOSESusceptibility source separationParkinson’s diseaseProdromal alpha-synucleinopathies |
| spellingShingle | Oliver C. Kiersnowski Pietro Mattioli Lucia Argenti Laura Avanzino Francesco Calizzano Andrea Diociasi Laura Falcitano Chunlei Liu Mattia Losa Federico Massa Silvia Morbelli Beatrice Orso Elisa Pelosin Stefano Raffa Matteo Pardini Dario Arnaldi Luca Roccatagliata Mauro Costagli Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies Scientific Reports Alpha-synucleinopathies Quantitative susceptibility mapping DECOMPOSE Susceptibility source separation Parkinson’s disease Prodromal alpha-synucleinopathies |
| title | Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies |
| title_full | Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies |
| title_fullStr | Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies |
| title_full_unstemmed | Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies |
| title_short | Magnetic susceptibility components reveal different aspects of neurodegeneration in alpha-synucleinopathies |
| title_sort | magnetic susceptibility components reveal different aspects of neurodegeneration in alpha synucleinopathies |
| topic | Alpha-synucleinopathies Quantitative susceptibility mapping DECOMPOSE Susceptibility source separation Parkinson’s disease Prodromal alpha-synucleinopathies |
| url | https://doi.org/10.1038/s41598-024-83593-z |
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