Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report
Introduction: Persistent apical periodontitis after root canal treatment may require surgical retreatment when non-surgical options are ineffective or impractical due to anatomical challenges or iatrogenic errors. Endodontic microsurgery (EMS) is a precise technique that aims to overcome extraradicu...
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024000334 |
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| author | Lucas Peixoto de Araújo Analu Rodriguez Marchesin Lucas Pinto Carpena Leandro Bueno Gobbo Nadia de Souza Ferreira José Flávio Affonso de Almeida Caio Cezar Randi Ferraz |
| author_facet | Lucas Peixoto de Araújo Analu Rodriguez Marchesin Lucas Pinto Carpena Leandro Bueno Gobbo Nadia de Souza Ferreira José Flávio Affonso de Almeida Caio Cezar Randi Ferraz |
| author_sort | Lucas Peixoto de Araújo |
| collection | DOAJ |
| description | Introduction: Persistent apical periodontitis after root canal treatment may require surgical retreatment when non-surgical options are ineffective or impractical due to anatomical challenges or iatrogenic errors. Endodontic microsurgery (EMS) is a precise technique that aims to overcome extraradicular biofilm and root morphology issues. Photodynamic therapy (PDT) is an emerging supplementary disinfection approach that utilizes a photosensitizer agent and light to eliminate microorganisms through oxidative reactions. Report: A 60-year-old male with persistent apical periodontitis in a left maxillary first molar underwent non-surgical root canal retreatment followed by surgical reintervention due to anatomical complexities. During surgery, PDT was performed using a novel curcumin-based photosensitizer agent. After the procedure, the tooth was retrofilled with bioceramic cement, and photobiomodulation was applied to enhance tissue healing. One year post-surgery, the patient exhibited complete periradicular repair and remained asymptomatic. Discussion: EMS is considered a last resort to salvage an endodontically treated tooth and has shown moderate success rates. PDT has demonstrated promise in improving periapical healing and reducing microorganisms. In this case, curcumin, diluted with 2 % chlorhexidine gel, served as an effective photosensitizer agent with antimicrobial properties. Moreover, performing photobiomodulation aided in cell recovery and reduced postoperative discomfort. Conclusion: The proposed EMS treatment protocol with PDT using curcumin yielded positive outcomes in this case report. Further randomized clinical trials are necessary to assess the efficacy of this approach in EMS. Additionally, further research on curcumin-based photosensitizer agents encapsulated in nanoparticles and enhanced antimicrobial agents is recommended to refine this treatment protocol for routine use. |
| format | Article |
| id | doaj-art-eaa47e16af704df9808b71b99ec2d728 |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-eaa47e16af704df9808b71b99ec2d7282025-08-20T01:54:51ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510399410.1016/j.pdpdt.2024.103994Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case reportLucas Peixoto de Araújo0Analu Rodriguez Marchesin1Lucas Pinto Carpena2Leandro Bueno Gobbo3Nadia de Souza Ferreira4José Flávio Affonso de Almeida5Caio Cezar Randi Ferraz6School of Dentistry, Catholic University of Pelotas (UCPEL), Pelotas, RS, Brazil; Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, SP, Brazil; Corresponding author at: Catholic University of Pelotas School of Dentistry Rua Gonçalves Chaves, 373 – Centro – Pelotas/RS.Department of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, SP, BrazilGraduate Program in Dentistry, School of Dentistry, Federal University of Pelotas (UFPEL), Pelotas, RS, BrazilDepartment of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, SP, BrazilGraduate Program in Dentistry, School of Dentistry, Federal University of Pelotas (UFPEL), Pelotas, RS, BrazilDepartment of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, SP, BrazilDepartment of Restorative Dentistry, Division of Endodontics, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, SP, BrazilIntroduction: Persistent apical periodontitis after root canal treatment may require surgical retreatment when non-surgical options are ineffective or impractical due to anatomical challenges or iatrogenic errors. Endodontic microsurgery (EMS) is a precise technique that aims to overcome extraradicular biofilm and root morphology issues. Photodynamic therapy (PDT) is an emerging supplementary disinfection approach that utilizes a photosensitizer agent and light to eliminate microorganisms through oxidative reactions. Report: A 60-year-old male with persistent apical periodontitis in a left maxillary first molar underwent non-surgical root canal retreatment followed by surgical reintervention due to anatomical complexities. During surgery, PDT was performed using a novel curcumin-based photosensitizer agent. After the procedure, the tooth was retrofilled with bioceramic cement, and photobiomodulation was applied to enhance tissue healing. One year post-surgery, the patient exhibited complete periradicular repair and remained asymptomatic. Discussion: EMS is considered a last resort to salvage an endodontically treated tooth and has shown moderate success rates. PDT has demonstrated promise in improving periapical healing and reducing microorganisms. In this case, curcumin, diluted with 2 % chlorhexidine gel, served as an effective photosensitizer agent with antimicrobial properties. Moreover, performing photobiomodulation aided in cell recovery and reduced postoperative discomfort. Conclusion: The proposed EMS treatment protocol with PDT using curcumin yielded positive outcomes in this case report. Further randomized clinical trials are necessary to assess the efficacy of this approach in EMS. Additionally, further research on curcumin-based photosensitizer agents encapsulated in nanoparticles and enhanced antimicrobial agents is recommended to refine this treatment protocol for routine use.http://www.sciencedirect.com/science/article/pii/S1572100024000334EndodonticsSurgeryEndodontic microsurgeryPhotodynamic Therapy |
| spellingShingle | Lucas Peixoto de Araújo Analu Rodriguez Marchesin Lucas Pinto Carpena Leandro Bueno Gobbo Nadia de Souza Ferreira José Flávio Affonso de Almeida Caio Cezar Randi Ferraz Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report Photodiagnosis and Photodynamic Therapy Endodontics Surgery Endodontic microsurgery Photodynamic Therapy |
| title | Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report |
| title_full | Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report |
| title_fullStr | Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report |
| title_full_unstemmed | Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report |
| title_short | Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report |
| title_sort | outcome of curcumin based photodynamic therapy in endodontic microsurgery a case report |
| topic | Endodontics Surgery Endodontic microsurgery Photodynamic Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024000334 |
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