Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors
Abstract. The outbreak of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has been influenced by the human response to the virus. These responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking a widespread response. Two importan...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2024-01-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000103 |
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| _version_ | 1850209849048039424 |
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| author | Matthew Halma Wei Zhao |
| author_facet | Matthew Halma Wei Zhao |
| author_sort | Matthew Halma |
| collection | DOAJ |
| description | Abstract. The outbreak of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has been influenced by the human response to the virus. These responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking a widespread response. Two important pharmaceutical interventions, vaccination and the utilization of medications, particularly molnupiravir, known to have mutagenic properties, were the focus of this article. The impact of molnupiravir on human health was evaluated through 3 mechanisms: viral resistance, mutagenesis of SARS-CoV-2, and mutagenesis occurring in patients undergoing treatment with molnupiravir. These mechanisms, as well as the impact of vaccination, have inadvertently given rise to unforeseen challenges in the management of the COVID-19 crisis. Taking a systems view in future pandemic responses, and taking into account the evolution of the pandemic virus, may be critical to ending the pandemic at an earlier date. |
| format | Article |
| id | doaj-art-eaa3e66b8a774112894535c685cc6804 |
| institution | OA Journals |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-eaa3e66b8a774112894535c685cc68042025-08-20T02:09:55ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392024-01-0141354010.1097/ID9.0000000000000103202401000-00005Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical FactorsMatthew Halma0Wei Zhao1EbMCsquared CIC, Bath BA2 4BL, United Kingdom.EbMCsquared CIC, Bath BA2 4BL, United Kingdom.Abstract. The outbreak of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has been influenced by the human response to the virus. These responses have undoubtedly impacted the evolutionary dynamics of the virus in ways distinct from a scenario lacking a widespread response. Two important pharmaceutical interventions, vaccination and the utilization of medications, particularly molnupiravir, known to have mutagenic properties, were the focus of this article. The impact of molnupiravir on human health was evaluated through 3 mechanisms: viral resistance, mutagenesis of SARS-CoV-2, and mutagenesis occurring in patients undergoing treatment with molnupiravir. These mechanisms, as well as the impact of vaccination, have inadvertently given rise to unforeseen challenges in the management of the COVID-19 crisis. Taking a systems view in future pandemic responses, and taking into account the evolution of the pandemic virus, may be critical to ending the pandemic at an earlier date.http://journals.lww.com/10.1097/ID9.0000000000000103 |
| spellingShingle | Matthew Halma Wei Zhao Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors Infectious Diseases & Immunity |
| title | Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors |
| title_full | Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors |
| title_fullStr | Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors |
| title_full_unstemmed | Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors |
| title_short | Alterations of SARS-CoV-2 Evolutionary Dynamics by Pharmaceutical Factors |
| title_sort | alterations of sars cov 2 evolutionary dynamics by pharmaceutical factors |
| url | http://journals.lww.com/10.1097/ID9.0000000000000103 |
| work_keys_str_mv | AT matthewhalma alterationsofsarscov2evolutionarydynamicsbypharmaceuticalfactors AT weizhao alterationsofsarscov2evolutionarydynamicsbypharmaceuticalfactors |