Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats
Objective: The Qinggan-27 (QG-27) recipe is a traditional Mongolian medicine believed to improve liver function during Non-alcoholic steatohepatitis (NASH). We developed fatty liver models in rats by intragastric administration of a high-fat diet (HFD) to investigate the effects of the QG-27 recipe...
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Mongolian National University of Medical Sciences
2024-09-01
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| Series: | Central Asian Journal of Medical Sciences |
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| Online Access: | https://www.mongoliajol.info/index.php/CAJMS/article/view/3949 |
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| author | WenJun Khaliun Erdenebat Tserentsoo Byambaa Bayarmaa Enkhbat Enkhtuguldur Myagmar-Ochir Sayamaa Lkhagvadorj |
| author_facet | WenJun Khaliun Erdenebat Tserentsoo Byambaa Bayarmaa Enkhbat Enkhtuguldur Myagmar-Ochir Sayamaa Lkhagvadorj |
| author_sort | WenJun |
| collection | DOAJ |
| description | Objective: The Qinggan-27 (QG-27) recipe is a traditional Mongolian medicine believed to improve liver function during Non-alcoholic steatohepatitis (NASH). We developed fatty liver models in rats by intragastric administration of a high-fat diet (HFD) to investigate the effects of the QG-27 recipe on the NASH model through the expression of PGC-1 α and UCP-2. Methods: Wister rats were fed with specially prepared HFD to create a pathological model for 6 weeks. After successful modeling, the patient was treated with QG-27 twice daily with intragastric administration of QG-27 at 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively, for 21 days. Biochemical, histopathological, and immunohistochemical analyses were conducted to evaluate the effect of QG-27 treatment. Results: Levels of AST, ALT, LDL-C, TG, and TC were significantly decreased, and HDL-C was increased in the intermediate dose of the QG-27 group compared to the control group (p<0.05). Immunohistochemical results demonstrated that an intermediate dose of the QG-27 recipe could significantly improve liver function in rats with fatty liver by increasing PGC-1α and UCP-2 expression. Conclusion: The intermediate (300 mg/ kg) dose of the QG-27 is a good candidate to be a dietary supplement for reducing fatty liver. |
| format | Article |
| id | doaj-art-eaa3209bb3f042ba8535660895ec23de |
| institution | Kabale University |
| issn | 2413-8681 2414-9772 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Mongolian National University of Medical Sciences |
| record_format | Article |
| series | Central Asian Journal of Medical Sciences |
| spelling | doaj-art-eaa3209bb3f042ba8535660895ec23de2025-08-20T03:25:26ZengMongolian National University of Medical SciencesCentral Asian Journal of Medical Sciences2413-86812414-97722024-09-01103859410.24079/cajms.2024.03.0013900Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in RatsWenJun0Khaliun Erdenebat1Tserentsoo Byambaa2Bayarmaa Enkhbat3Enkhtuguldur Myagmar-Ochir4Sayamaa Lkhagvadorj5https://orcid.org/0000-0001-6924-8715Department of Traditional Prescriptionology, International School of Mongolian Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Pathology and Forensic Medicine, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Traditional Prescriptionology, International School of Mongolian Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Pathology and Forensic Medicine, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of epidemiology and biostatistics, School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Pathology and Forensic Medicine, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaObjective: The Qinggan-27 (QG-27) recipe is a traditional Mongolian medicine believed to improve liver function during Non-alcoholic steatohepatitis (NASH). We developed fatty liver models in rats by intragastric administration of a high-fat diet (HFD) to investigate the effects of the QG-27 recipe on the NASH model through the expression of PGC-1 α and UCP-2. Methods: Wister rats were fed with specially prepared HFD to create a pathological model for 6 weeks. After successful modeling, the patient was treated with QG-27 twice daily with intragastric administration of QG-27 at 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively, for 21 days. Biochemical, histopathological, and immunohistochemical analyses were conducted to evaluate the effect of QG-27 treatment. Results: Levels of AST, ALT, LDL-C, TG, and TC were significantly decreased, and HDL-C was increased in the intermediate dose of the QG-27 group compared to the control group (p<0.05). Immunohistochemical results demonstrated that an intermediate dose of the QG-27 recipe could significantly improve liver function in rats with fatty liver by increasing PGC-1α and UCP-2 expression. Conclusion: The intermediate (300 mg/ kg) dose of the QG-27 is a good candidate to be a dietary supplement for reducing fatty liver.https://www.mongoliajol.info/index.php/CAJMS/article/view/3949disease modelnon-alcoholic fatty livermongolian medicinepgc-1αucp-2 |
| spellingShingle | WenJun Khaliun Erdenebat Tserentsoo Byambaa Bayarmaa Enkhbat Enkhtuguldur Myagmar-Ochir Sayamaa Lkhagvadorj Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats Central Asian Journal of Medical Sciences disease model non-alcoholic fatty liver mongolian medicine pgc-1α ucp-2 |
| title | Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats |
| title_full | Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats |
| title_fullStr | Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats |
| title_full_unstemmed | Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats |
| title_short | Effects of Qinggan-27 Recipe on Nonalcoholic Steatohepatitis Induced by High-fat Diet in Rats |
| title_sort | effects of qinggan 27 recipe on nonalcoholic steatohepatitis induced by high fat diet in rats |
| topic | disease model non-alcoholic fatty liver mongolian medicine pgc-1α ucp-2 |
| url | https://www.mongoliajol.info/index.php/CAJMS/article/view/3949 |
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