The reprogramming impact of SMAC-mimetic on glioblastoma stem cells and the immune tumor microenvironment evolution

The reprogramming impact of SMAC-mimetic on glioblastoma stem cells and the immune tumor microenvironment evolution

Abstract Background Intrinsically resistant glioma stem cells (GSCs) in the setting of a highly immunosuppressive tumor microenvironment (TME) remain the most predominant phenomenon leading to unfavorable therapeutic outcomes in glioblastoma (GBM). Hence there is an unmet need for novel anti-GBM the...

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Bibliographic Details
Main Authors: Qiong Wu, Jianan Chen, Anders E. Berglund, Dongliang Du, Robert J. Macaulay, Arnold B. Etame
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:https://doi.org/10.1186/s13046-025-03452-1
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