Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy
Purpose: To investigate the functional and structural daily variations in eyes with a mild form of Fuchs’ endothelial corneal dystrophy (FECD). Methods: This prospective study included 30 eyes with the mild form of FECD. Subjects underwent functional and structural testing at 8 AM, 2 PM, and 8 PM. T...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_282_24 |
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| author | Iva Krolo Aida Kasumović Bećirević Ivana Radman Armin Kasumović Ines Matoc Idoia Goñi Guarro Ivan Sabol |
| author_facet | Iva Krolo Aida Kasumović Bećirević Ivana Radman Armin Kasumović Ines Matoc Idoia Goñi Guarro Ivan Sabol |
| author_sort | Iva Krolo |
| collection | DOAJ |
| description | Purpose:
To investigate the functional and structural daily variations in eyes with a mild form of Fuchs’ endothelial corneal dystrophy (FECD).
Methods:
This prospective study included 30 eyes with the mild form of FECD. Subjects underwent functional and structural testing at 8 AM, 2 PM, and 8 PM. Testing included measurement of uncorrected distance visual acuity (UDVA), best corrected twilight vision (TV), and contrast sensitivity function (CSF) testing (Vista Vision Far-Pola, DMD MedTech charts). Corneal epithelial and stromal parameters were evaluated with anterior segment optical coherence tomography (AngioVue, AvantiRTVue-XR; Optovue, CA, USA).
Results:
UDVA, TV, and CSF for spatial frequencies B, C, and F showed significant changes during the day, with the lowest values in the morning (P < 0.0001 for UDVA, P = 0.0109 for TV, and P < 0.0001, P = 0.0126, and P = 0.0471 for the three spatial frequencies, respectively). There was no significant change in epithelial parameters between visits. Central corneal thickness showed significant decrease during the day (P < 0.0001), as did the central stromal thickness on the 5- and 7-mm maps (P = 0.0002 and P < 0.0001, respectively), stromal thickness in the superior section of the 5-mm map (P = 0.0107), stromal thickness in the inferior section of the 7-mm map (P = 0.0002), and minimal stromal thickness on both maps (P < 0.0001).
Conclusion:
A significant negative correlation was found between central stromal thickness and TV, implying that simultaneous evaluation of corneal layers and visual quality may be useful in assessing FECD. |
| format | Article |
| id | doaj-art-eaa195629a6a4f48941c481bd450ced6 |
| institution | OA Journals |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-eaa195629a6a4f48941c481bd450ced62025-08-20T01:48:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173112212710.4103/IJO.IJO_282_24Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophyIva KroloAida Kasumović BećirevićIvana RadmanArmin KasumovićInes MatocIdoia Goñi GuarroIvan SabolPurpose: To investigate the functional and structural daily variations in eyes with a mild form of Fuchs’ endothelial corneal dystrophy (FECD). Methods: This prospective study included 30 eyes with the mild form of FECD. Subjects underwent functional and structural testing at 8 AM, 2 PM, and 8 PM. Testing included measurement of uncorrected distance visual acuity (UDVA), best corrected twilight vision (TV), and contrast sensitivity function (CSF) testing (Vista Vision Far-Pola, DMD MedTech charts). Corneal epithelial and stromal parameters were evaluated with anterior segment optical coherence tomography (AngioVue, AvantiRTVue-XR; Optovue, CA, USA). Results: UDVA, TV, and CSF for spatial frequencies B, C, and F showed significant changes during the day, with the lowest values in the morning (P < 0.0001 for UDVA, P = 0.0109 for TV, and P < 0.0001, P = 0.0126, and P = 0.0471 for the three spatial frequencies, respectively). There was no significant change in epithelial parameters between visits. Central corneal thickness showed significant decrease during the day (P < 0.0001), as did the central stromal thickness on the 5- and 7-mm maps (P = 0.0002 and P < 0.0001, respectively), stromal thickness in the superior section of the 5-mm map (P = 0.0107), stromal thickness in the inferior section of the 7-mm map (P = 0.0002), and minimal stromal thickness on both maps (P < 0.0001). Conclusion: A significant negative correlation was found between central stromal thickness and TV, implying that simultaneous evaluation of corneal layers and visual quality may be useful in assessing FECD.https://journals.lww.com/10.4103/IJO.IJO_282_24anterior segment optical coherence tomographyepithelial corneal mapsfuchs’ corneal dystrophystromal corneal mapsvisual quality |
| spellingShingle | Iva Krolo Aida Kasumović Bećirević Ivana Radman Armin Kasumović Ines Matoc Idoia Goñi Guarro Ivan Sabol Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy Indian Journal of Ophthalmology anterior segment optical coherence tomography epithelial corneal maps fuchs’ corneal dystrophy stromal corneal maps visual quality |
| title | Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy |
| title_full | Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy |
| title_fullStr | Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy |
| title_full_unstemmed | Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy |
| title_short | Diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of Fuchs’ endothelial corneal dystrophy |
| title_sort | diurnal changes of corneal epithelial and stromal thickness maps and visual quality in mild form of fuchs endothelial corneal dystrophy |
| topic | anterior segment optical coherence tomography epithelial corneal maps fuchs’ corneal dystrophy stromal corneal maps visual quality |
| url | https://journals.lww.com/10.4103/IJO.IJO_282_24 |
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