Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol
Introduction Mechanical ventilatory is a crucial element of acute brain injured patients’ management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can...
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BMJ Publishing Group
2021-08-01
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| Online Access: | https://bmjopen.bmj.com/content/11/8/e047100.full |
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| author | Raimund Helbok Karim Asehnoune Giuseppe Citerio Geert Meyfroidt Nino Stocchetti Chiara Robba Alessia Vargiolu Jordi Mancebo Christian Putensen Rafael Badenes John Laffey Robert Stevens Paolo Pelosi Raphaël Cinotti Stefania Galimberti Paola Rebora Fabio S Taccone Maura Mandelli Valentina Della Torre Jose’ Suarez Marcelo Gama De Abreu Marcus Schultz Louis Blanch |
| author_facet | Raimund Helbok Karim Asehnoune Giuseppe Citerio Geert Meyfroidt Nino Stocchetti Chiara Robba Alessia Vargiolu Jordi Mancebo Christian Putensen Rafael Badenes John Laffey Robert Stevens Paolo Pelosi Raphaël Cinotti Stefania Galimberti Paola Rebora Fabio S Taccone Maura Mandelli Valentina Della Torre Jose’ Suarez Marcelo Gama De Abreu Marcus Schultz Louis Blanch |
| author_sort | Raimund Helbok |
| collection | DOAJ |
| description | Introduction Mechanical ventilatory is a crucial element of acute brain injured patients’ management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can draw conclusions regarding optimal ventilator management in this setting.Methods and analysis This is an international multicentre prospective observational cohort study. The aim of the ‘multicentre observational study on practice of ventilation in brain injured patients’—the VENTIBRAIN study—is to describe the current practice of ventilator settings and mechanical ventilation in acute brain injured patients. Secondary objectives include the description of ventilator settings among different countries, and their association with outcomes. Inclusion criteria will be adult patients admitted to the intensive care unit (ICU) with a diagnosis of traumatic brain injury or cerebrovascular diseases (intracranial haemorrhage, subarachnoid haemorrhage, ischaemic stroke), requiring intubation and mechanical ventilation and admission to the ICU. Exclusion criteria will be the following: patients aged <18 years; pregnant patients; patients not intubated or not mechanically ventilated or receiving only non-invasive ventilation. Data related to clinical examination, neuromonitoring if available, ventilator settings and arterial blood gases will be recorded at admission and daily for the first 7 days and then at day 10 and 14. The Glasgow Outcome Scale Extended on mortality and neurological outcome will be collected at discharge from ICU, hospital and at 6 months follow-up.Ethics and dissemination The study has been approved by the Ethic committee of Brianza at the Azienda Socio Sanitaria Territoriale-Monza. Data will be disseminated to the scientific community by abstracts submitted to the European Society of Intensive Care Medicine annual conference and by original articles submitted to peer-reviewed journals.Trial registration number NCT04459884. |
| format | Article |
| id | doaj-art-eaa0f09c333f464d832c4282a8b19b5f |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-eaa0f09c333f464d832c4282a8b19b5f2025-08-20T02:20:38ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-047100Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocolRaimund HelbokKarim Asehnoune0Giuseppe Citerio1Geert Meyfroidt2Nino StocchettiChiara Robba3Alessia Vargiolu4Jordi Mancebo5Christian Putensen6Rafael Badenes7John Laffey8Robert StevensPaolo Pelosi9Raphaël Cinotti10Stefania Galimberti11Paola Rebora12Fabio S Taccone13Maura MandelliValentina Della TorreJose’ SuarezMarcelo Gama De AbreuMarcus SchultzLouis Blanch3 Département Anesthésie Réanimation, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, FranceSchool of Medicine and Surgery, University of Milano - Bicocca, Monza, Italy6 Intensieve geneeskunde, Universitaire Ziekenhuizen Leuven, Leuven, BelgiumDepartment of Anesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, ItalySchool of Medicine and Surgery, Università Miano - Bicocca, Milano, ItalyHospital de la Santa Creu i Sant Pau Institut de Recerca, Barcelona, SpainDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, GermanyDepartment of Anesthesiology and Surgical-Trauma Intensive Care, Hospital Clinic Universitari de València, Universitat de València, Valencia, SpainDepartment of Anaesthesia and Intensive Care Medicine, School of Medicine, National University of Ireland Galway, Galway, IrelandDepartment of Anesthesia and Critical Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neuroscience, Genoa, ItalyAnaesthesia and Intensive Care Unit, Hôpital Laennec, Saint-Herblain, University Hospital of Nantes, Université de Nantes, CHU Nantes, Nantes, FranceSchool of Medicine and Surgery, University of Milano - Bicocca, Monza, ItalySchool of Medicine and Surgery, University of Milano - Bicocca, Monza, ItalyDpt of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles, Bruxelles, BelgiumIntroduction Mechanical ventilatory is a crucial element of acute brain injured patients’ management. The ventilatory goals to ensure lung protection during acute respiratory failure may not be adequate in case of concomitant brain injury. Therefore, there are limited data from which physicians can draw conclusions regarding optimal ventilator management in this setting.Methods and analysis This is an international multicentre prospective observational cohort study. The aim of the ‘multicentre observational study on practice of ventilation in brain injured patients’—the VENTIBRAIN study—is to describe the current practice of ventilator settings and mechanical ventilation in acute brain injured patients. Secondary objectives include the description of ventilator settings among different countries, and their association with outcomes. Inclusion criteria will be adult patients admitted to the intensive care unit (ICU) with a diagnosis of traumatic brain injury or cerebrovascular diseases (intracranial haemorrhage, subarachnoid haemorrhage, ischaemic stroke), requiring intubation and mechanical ventilation and admission to the ICU. Exclusion criteria will be the following: patients aged <18 years; pregnant patients; patients not intubated or not mechanically ventilated or receiving only non-invasive ventilation. Data related to clinical examination, neuromonitoring if available, ventilator settings and arterial blood gases will be recorded at admission and daily for the first 7 days and then at day 10 and 14. The Glasgow Outcome Scale Extended on mortality and neurological outcome will be collected at discharge from ICU, hospital and at 6 months follow-up.Ethics and dissemination The study has been approved by the Ethic committee of Brianza at the Azienda Socio Sanitaria Territoriale-Monza. Data will be disseminated to the scientific community by abstracts submitted to the European Society of Intensive Care Medicine annual conference and by original articles submitted to peer-reviewed journals.Trial registration number NCT04459884.https://bmjopen.bmj.com/content/11/8/e047100.full |
| spellingShingle | Raimund Helbok Karim Asehnoune Giuseppe Citerio Geert Meyfroidt Nino Stocchetti Chiara Robba Alessia Vargiolu Jordi Mancebo Christian Putensen Rafael Badenes John Laffey Robert Stevens Paolo Pelosi Raphaël Cinotti Stefania Galimberti Paola Rebora Fabio S Taccone Maura Mandelli Valentina Della Torre Jose’ Suarez Marcelo Gama De Abreu Marcus Schultz Louis Blanch Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol BMJ Open |
| title | Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol |
| title_full | Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol |
| title_fullStr | Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol |
| title_full_unstemmed | Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol |
| title_short | Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol |
| title_sort | multicentre observational study on practice of ventilation in brain injured patients the ventibrain study protocol |
| url | https://bmjopen.bmj.com/content/11/8/e047100.full |
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