Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients
BackgroundSurgical treatment of functional single ventricle combined with atrioventricular valve regurgitation remains a clinical challenge. The outcomes of atrioventricular valve repair in patients with single ventricle are limited.MethodsA retrospective study was conducted of all 28 patients with...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1510143/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850112468644265984 |
|---|---|
| author | Yong-Qiang Jin Yong-Qiang Jin Qing-Yu Wu Qing-Yu Wu Xiao-Ya Zhang Xiao-Ya Zhang Li-Xin Fan En-Rui Zhang Hui Xue Ming-Kui Zhang Ming-Kui Zhang |
| author_facet | Yong-Qiang Jin Yong-Qiang Jin Qing-Yu Wu Qing-Yu Wu Xiao-Ya Zhang Xiao-Ya Zhang Li-Xin Fan En-Rui Zhang Hui Xue Ming-Kui Zhang Ming-Kui Zhang |
| author_sort | Yong-Qiang Jin |
| collection | DOAJ |
| description | BackgroundSurgical treatment of functional single ventricle combined with atrioventricular valve regurgitation remains a clinical challenge. The outcomes of atrioventricular valve repair in patients with single ventricle are limited.MethodsA retrospective study was conducted of all 28 patients with functional single ventricle treated with single-ventricle palliation who underwent atrioventricular valve operation at the First Hospital of Tsinghua University between April 2007 and October 2022.ResultsIn our cohort, the female/male ratio was 7:21, with an average age of 8.7 ± 6.0 (0.75–26) years. Half of patients (50%) were right-ventricle type for single-ventricle morphology. 18 patients (64.3%) were with a common atrioventricular valve. Twenty-three patients (82.1%) were combined with heterotaxy syndrome. Pre-operatively, twenty-four patients (85.7%) were diagnosed with severe atrioventricular valve regurgitation. AVV was repaired at the Glenn (n = 16, 57.1%), Glenn-Fontan (n = 2, 7.1%) and Fontan (n = 10, 35.7%) stage, respectively. Valve plastic techniques included valve annulus/commissure constriction (n = 24), clefts repair (9 cases), edge-to-edge suturing (13 cases) and common atrioventricular valve separation (4 cases). The early mortality was 3.6% (1/28). All survival patients were observed with improved regurgitation situations. Twenty-two patients (78.5%) were observed with no more than mild regurgitation postoperatively. The mean follow-up time was 5.4 ± 2.9 years (range, 3.08–11.83 years), with late mortality of 11.1% (3/27). All these three cases were observed with a severe regurgitation by echocardiogram in the last follow-up. Besides, reoperation rate of this cohort was 3.6% (1/28).ConclusionsAVV repair could significantly improve AVV function in SV patients combined with severe AVVR, with satisfactory mid-term results. Part of the cohort showed poor prognosis due to repeated AVVR. Regular follow-up by echocardiogram is critically important for these patients. |
| format | Article |
| id | doaj-art-ea979a389e484f7fad3e0b4c1555c1ca |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-ea979a389e484f7fad3e0b4c1555c1ca2025-08-20T02:37:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-12-011110.3389/fcvm.2024.15101431510143Mid-term outcomes of atrioventricular valve repair in functional single ventricle patientsYong-Qiang Jin0Yong-Qiang Jin1Qing-Yu Wu2Qing-Yu Wu3Xiao-Ya Zhang4Xiao-Ya Zhang5Li-Xin Fan6En-Rui Zhang7Hui Xue8Ming-Kui Zhang9Ming-Kui Zhang10Heart Center, The First Hospital of Tsinghua University, Beijing, ChinaSchool of Clinical Medicine, Tsinghua University, Beijing, ChinaHeart Center, The First Hospital of Tsinghua University, Beijing, ChinaSchool of Clinical Medicine, Tsinghua University, Beijing, ChinaHeart Center, The First Hospital of Tsinghua University, Beijing, ChinaSchool of Clinical Medicine, Tsinghua University, Beijing, ChinaHeart Center, The First Hospital of Tsinghua University, Beijing, ChinaHeart Center, The First Hospital of Tsinghua University, Beijing, ChinaHeart Center, The First Hospital of Tsinghua University, Beijing, ChinaHeart Center, The First Hospital of Tsinghua University, Beijing, ChinaSchool of Clinical Medicine, Tsinghua University, Beijing, ChinaBackgroundSurgical treatment of functional single ventricle combined with atrioventricular valve regurgitation remains a clinical challenge. The outcomes of atrioventricular valve repair in patients with single ventricle are limited.MethodsA retrospective study was conducted of all 28 patients with functional single ventricle treated with single-ventricle palliation who underwent atrioventricular valve operation at the First Hospital of Tsinghua University between April 2007 and October 2022.ResultsIn our cohort, the female/male ratio was 7:21, with an average age of 8.7 ± 6.0 (0.75–26) years. Half of patients (50%) were right-ventricle type for single-ventricle morphology. 18 patients (64.3%) were with a common atrioventricular valve. Twenty-three patients (82.1%) were combined with heterotaxy syndrome. Pre-operatively, twenty-four patients (85.7%) were diagnosed with severe atrioventricular valve regurgitation. AVV was repaired at the Glenn (n = 16, 57.1%), Glenn-Fontan (n = 2, 7.1%) and Fontan (n = 10, 35.7%) stage, respectively. Valve plastic techniques included valve annulus/commissure constriction (n = 24), clefts repair (9 cases), edge-to-edge suturing (13 cases) and common atrioventricular valve separation (4 cases). The early mortality was 3.6% (1/28). All survival patients were observed with improved regurgitation situations. Twenty-two patients (78.5%) were observed with no more than mild regurgitation postoperatively. The mean follow-up time was 5.4 ± 2.9 years (range, 3.08–11.83 years), with late mortality of 11.1% (3/27). All these three cases were observed with a severe regurgitation by echocardiogram in the last follow-up. Besides, reoperation rate of this cohort was 3.6% (1/28).ConclusionsAVV repair could significantly improve AVV function in SV patients combined with severe AVVR, with satisfactory mid-term results. Part of the cohort showed poor prognosis due to repeated AVVR. Regular follow-up by echocardiogram is critically important for these patients.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1510143/fullsingle-ventricleatrioventricular valve repairFontanGlennoperation timing |
| spellingShingle | Yong-Qiang Jin Yong-Qiang Jin Qing-Yu Wu Qing-Yu Wu Xiao-Ya Zhang Xiao-Ya Zhang Li-Xin Fan En-Rui Zhang Hui Xue Ming-Kui Zhang Ming-Kui Zhang Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients Frontiers in Cardiovascular Medicine single-ventricle atrioventricular valve repair Fontan Glenn operation timing |
| title | Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients |
| title_full | Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients |
| title_fullStr | Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients |
| title_full_unstemmed | Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients |
| title_short | Mid-term outcomes of atrioventricular valve repair in functional single ventricle patients |
| title_sort | mid term outcomes of atrioventricular valve repair in functional single ventricle patients |
| topic | single-ventricle atrioventricular valve repair Fontan Glenn operation timing |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1510143/full |
| work_keys_str_mv | AT yongqiangjin midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT yongqiangjin midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT qingyuwu midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT qingyuwu midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT xiaoyazhang midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT xiaoyazhang midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT lixinfan midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT enruizhang midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT huixue midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT mingkuizhang midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients AT mingkuizhang midtermoutcomesofatrioventricularvalverepairinfunctionalsingleventriclepatients |