Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies
[Objective] To investigate the factors associated with alanine aminotransferase (ALT) abnormalities in multi-ethnic blood donors across five Zang autonomous prefectures in the plateau regions of Qinghai Province, and to provide evidence for ensuring blood safety and formulating screening strategies....
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-04-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.007&lang=en |
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| author | DANG Yingnan Shana Halemubieke TANG Rong HUANG Liqin WU Hailin CHEN Tingting LI Shengju SUN Yanli ZHENG Xin LI Yanxia YE Xianlin ZENG Jinfeng |
| author_facet | DANG Yingnan Shana Halemubieke TANG Rong HUANG Liqin WU Hailin CHEN Tingting LI Shengju SUN Yanli ZHENG Xin LI Yanxia YE Xianlin ZENG Jinfeng |
| author_sort | DANG Yingnan |
| collection | DOAJ |
| description | [Objective] To investigate the factors associated with alanine aminotransferase (ALT) abnormalities in multi-ethnic blood donors across five Zang autonomous prefectures in the plateau regions of Qinghai Province, and to provide evidence for ensuring blood safety and formulating screening strategies. [Methods] A retrospective analysis was performed on the ALT abnormal test results of blood donors in the Zang autonomous prefectures of Qinghai from 2022 to 2024. The correlations between ALT levels and factors including gender, age, altitude, and infectious markers were investigated. [Results] The overall ALT unqualified rate among blood donors in this region was 9.01%. Significant differences in ALT levels were observed across genders and age groups (P<0.05). Variations in ALT abnormality rates were also noted among different plateau regions (P<0.05). Overall, ALT values exhibited an increasing trend with rising altitude. The average ALT unqualified rates were 11.19% in Zang donors, 7.96% in Han donors, and 4.79% in donors from other ethnic groups (P<0.05). No statistically significant association was observed between ALT abnormality and the presence of HBV/HCV infectious markers (P>0.05). [Conclusion] In the plateau areas of Qinghai, multi-ethnic blood donors have a relatively high ALT levels and ALT unqualified rates, showing distinct regional characteristics. ALT elevation in voluntary blood donors is related to non-pathological factors such as gender, age, and dietary habits, but not to infectious indicators. |
| format | Article |
| id | doaj-art-ea92403b9bfa41fdbb257733bb37befd |
| institution | DOAJ |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-ea92403b9bfa41fdbb257733bb37befd2025-08-20T02:56:12ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-04-0138450250710.13303/j.cjbt.issn.1004-549x.2025.04.0071004-549X(2025)4-0502-06Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategiesDANG Yingnan0Shana Halemubieke1TANG Rong2HUANG Liqin3WU Hailin4CHEN Tingting5LI Shengju6SUN Yanli7ZHENG Xin8LI Yanxia9YE Xianlin10ZENG Jinfeng11Qinghai Provincial Blood Center, Xining 810000, ChinaNational Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing 100730, ChinaKunming Blood Center, Kunming 650106, ChinaShenzhen Blood Center, Shenzhen 518035, ChinaQinghai Provincial Blood Center, Xining 810000, ChinaShenzhen Blood Center, Shenzhen 518035, ChinaQinghai Provincial Blood Center, Xining 810000, ChinaShenzhen Blood Center, Shenzhen 518035, ChinaShenzhen Blood Center, Shenzhen 518035, ChinaQinghai Provincial Blood Center, Xining 810000, ChinaShenzhen Blood Center, Shenzhen 518035, ChinaShenzhen Blood Center, Shenzhen 518035, China[Objective] To investigate the factors associated with alanine aminotransferase (ALT) abnormalities in multi-ethnic blood donors across five Zang autonomous prefectures in the plateau regions of Qinghai Province, and to provide evidence for ensuring blood safety and formulating screening strategies. [Methods] A retrospective analysis was performed on the ALT abnormal test results of blood donors in the Zang autonomous prefectures of Qinghai from 2022 to 2024. The correlations between ALT levels and factors including gender, age, altitude, and infectious markers were investigated. [Results] The overall ALT unqualified rate among blood donors in this region was 9.01%. Significant differences in ALT levels were observed across genders and age groups (P<0.05). Variations in ALT abnormality rates were also noted among different plateau regions (P<0.05). Overall, ALT values exhibited an increasing trend with rising altitude. The average ALT unqualified rates were 11.19% in Zang donors, 7.96% in Han donors, and 4.79% in donors from other ethnic groups (P<0.05). No statistically significant association was observed between ALT abnormality and the presence of HBV/HCV infectious markers (P>0.05). [Conclusion] In the plateau areas of Qinghai, multi-ethnic blood donors have a relatively high ALT levels and ALT unqualified rates, showing distinct regional characteristics. ALT elevation in voluntary blood donors is related to non-pathological factors such as gender, age, and dietary habits, but not to infectious indicators.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.007&lang=enplateaumulti-ethnicalanine aminotransferase (alt)blood resourcesscreening strategies |
| spellingShingle | DANG Yingnan Shana Halemubieke TANG Rong HUANG Liqin WU Hailin CHEN Tingting LI Shengju SUN Yanli ZHENG Xin LI Yanxia YE Xianlin ZENG Jinfeng Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies Zhongguo shuxue zazhi plateau multi-ethnic alanine aminotransferase (alt) blood resources screening strategies |
| title | Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies |
| title_full | Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies |
| title_fullStr | Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies |
| title_full_unstemmed | Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies |
| title_short | Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies |
| title_sort | analysis of abnormal alt in blood donors in five zang autonomous prefectures of qinghai province china characteristics and screening strategies |
| topic | plateau multi-ethnic alanine aminotransferase (alt) blood resources screening strategies |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.007&lang=en |
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