Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls
IntroductionSubstance use disorders are often associated with impairments in cognitive and behavioral processes. Methamphetamine use disorder (MUD), in particular, has been linked to such differences, though it remains unclear whether response inhibition (the inability to withhold prepotent response...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1604252/full |
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| author | M. Frances Vest M. Frances Vest Alexandru Mihai Dumitrescu Alexandru Mihai Dumitrescu Matthew W. Johnson Elliot Thompson Elliot Thompson Alfred Thomas James C. Patterson James C. Patterson James C. Patterson Kevin S. Murnane Kevin S. Murnane Kevin S. Murnane |
| author_facet | M. Frances Vest M. Frances Vest Alexandru Mihai Dumitrescu Alexandru Mihai Dumitrescu Matthew W. Johnson Elliot Thompson Elliot Thompson Alfred Thomas James C. Patterson James C. Patterson James C. Patterson Kevin S. Murnane Kevin S. Murnane Kevin S. Murnane |
| author_sort | M. Frances Vest |
| collection | DOAJ |
| description | IntroductionSubstance use disorders are often associated with impairments in cognitive and behavioral processes. Methamphetamine use disorder (MUD), in particular, has been linked to such differences, though it remains unclear whether response inhibition (the inability to withhold prepotent responses), risk taking, or other constructs play more prominent roles. Understanding the specific contributions of these constructs is essential for tailoring interventions and improving outcomes for individuals with MUD. This study aimed to investigate both subdomains of impulsivity in individuals recently abstinent from methamphetamine.MethodsParticipants with MUD (n=29) recruited from 30-day residential treatment programs and age-matched controls (n =27) completed the Iowa Gambling Task (IGT) and Balloon Analogue Risk Task (BART) to assess risk taking and delay sensitivity, and the Stroop Color and Word Task (SCWT) and Stop Signal Task (SST) to assess response inhibition. Two-way multivariate analyses of covariance (MANCOVAs) were performed to determine group differences.ResultsAnalyses revealed no significant group differences in IGT net score (p=0.62) and BART average pumps (p=0.45). Conversely, significant differences emerged in as evidenced by longer stop signal reaction times (p < 0.01) and lower SCWT accuracy (p=0.03) in the MUD group compared to age-matched controls.DiscussionThese findings suggest that methamphetamine use disorder is associated with specific cognitive and behavioral abnormalities. Targeting these constructs in treatment may improve outcomes for individuals recovering from MUD. |
| format | Article |
| id | doaj-art-ea8f8008604f43f1beb86dc9c637e68a |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-ea8f8008604f43f1beb86dc9c637e68a2025-08-20T03:49:49ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-07-011610.3389/fpsyt.2025.16042521604252Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controlsM. Frances Vest0M. Frances Vest1Alexandru Mihai Dumitrescu2Alexandru Mihai Dumitrescu3Matthew W. Johnson4Elliot Thompson5Elliot Thompson6Alfred Thomas7James C. Patterson8James C. Patterson9James C. Patterson10Kevin S. Murnane11Kevin S. Murnane12Kevin S. Murnane13Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesLouisiana Addiction Research Center, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesLouisiana Addiction Research Center, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesSheppard Pratt, Baltimore, MD, United StatesLouisiana Addiction Research Center, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesLouisiana Addiction Research Center, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesLouisiana Addiction Research Center, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesDepartment of Psychiatry and Behavioral Medicine, Louisiana State University Health Science Center Shreveport, Shreveport, LA, United StatesIntroductionSubstance use disorders are often associated with impairments in cognitive and behavioral processes. Methamphetamine use disorder (MUD), in particular, has been linked to such differences, though it remains unclear whether response inhibition (the inability to withhold prepotent responses), risk taking, or other constructs play more prominent roles. Understanding the specific contributions of these constructs is essential for tailoring interventions and improving outcomes for individuals with MUD. This study aimed to investigate both subdomains of impulsivity in individuals recently abstinent from methamphetamine.MethodsParticipants with MUD (n=29) recruited from 30-day residential treatment programs and age-matched controls (n =27) completed the Iowa Gambling Task (IGT) and Balloon Analogue Risk Task (BART) to assess risk taking and delay sensitivity, and the Stroop Color and Word Task (SCWT) and Stop Signal Task (SST) to assess response inhibition. Two-way multivariate analyses of covariance (MANCOVAs) were performed to determine group differences.ResultsAnalyses revealed no significant group differences in IGT net score (p=0.62) and BART average pumps (p=0.45). Conversely, significant differences emerged in as evidenced by longer stop signal reaction times (p < 0.01) and lower SCWT accuracy (p=0.03) in the MUD group compared to age-matched controls.DiscussionThese findings suggest that methamphetamine use disorder is associated with specific cognitive and behavioral abnormalities. Targeting these constructs in treatment may improve outcomes for individuals recovering from MUD.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1604252/fullmethamphetamineresponse inhibitionrisk takingaddictionCognitiondelay sensitivity |
| spellingShingle | M. Frances Vest M. Frances Vest Alexandru Mihai Dumitrescu Alexandru Mihai Dumitrescu Matthew W. Johnson Elliot Thompson Elliot Thompson Alfred Thomas James C. Patterson James C. Patterson James C. Patterson Kevin S. Murnane Kevin S. Murnane Kevin S. Murnane Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls Frontiers in Psychiatry methamphetamine response inhibition risk taking addiction Cognition delay sensitivity |
| title | Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls |
| title_full | Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls |
| title_fullStr | Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls |
| title_full_unstemmed | Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls |
| title_short | Individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age-matched controls |
| title_sort | individuals recently abstinent from methamphetamine show selective cognitive and behavioral differences when compared to age matched controls |
| topic | methamphetamine response inhibition risk taking addiction Cognition delay sensitivity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1604252/full |
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