Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis

Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis

ObjectiveEstablishing biomarkers to predict multiple sclerosis (MS) disability accrual has been challenging using a single biomarker approach, likely due to the complex interplay of neuroinflammation and neurodegeneration. Here, we aimed to investigate the prognostic value of single and multimodal b...

Full description

Saved in:

Bibliographic Details
Main Authors:	Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	multiple sclerosis biomarker magnetic resonance imaging neurofilament optical coherence tomography disease progression
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532660/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Cerebral cortex contributions to Parkinson’s disease tremor: what exactly generates the tremor?
by: Manuel Bange, et al.
Published: (2025-12-01)

Serum neurofilament heavy chains as a biomarker of neuronal damage in multiple sclerosis relapse
by: P. Beliaziūnas, et al.
Published: (2021-03-01)

Familial Case of Cherubism from South India: Differential Diagnosis and Report of 2 Cases
by: Varun Muthuraman, et al.
Published: (2014-01-01)

Electrophysiological approaches to informing therapeutic interventions with deep brain stimulation
by: Atefeh Asadi, et al.
Published: (2025-01-01)

The role of neurofilament light chain in the context of neurological disorders
by: V. Taluntienė, et al.
Published: (2020-12-01)

Prognostic Value of Cerebrospinal Fluid and Serum Neurofilament Light Chain in Amyotrophic Lateral Sclerosis: A Correlation Study
by: Siqi Dong, et al.
Published: (2025-01-01)

Functional and Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: Cognitive Tests and Plasma Neurofilament Light Chain Levels
by: Elina Polunosika, et al.
Published: (2025-01-01)

Shared prognostic information in amyotrophic lateral sclerosis – systematic assessment of the patients’ perception of neurofilament light chain and the ALS functional rating scale
by: Lukas Maximilian Möhwald, et al.
Published: (2025-02-01)

No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients
by: Bartosz Gajewski, et al.
Published: (2025-01-01)

NF-κB Inhibitory Activity of the Di-Hydroxy Derivative of Piperlongumine (PL-18)
by: Yael Schlichter Kadosh, et al.
Published: (2025-01-01)

Determinants of Chronic Kidney Disease among Young Adults attending a Tertiary Care Hospital in Madurai- A Case-Control Study
by: Sridevi PN, et al.
Published: (2024-12-01)

Paraneoplastic Autoimmunity in Thymus Tumors
by: Alexander Marx, et al.
Published: (1998-01-01)

Barriers in Healthcare to the Use of Optical Coherence Tomography Angiography in Multiple Sclerosis
by: Lukas G. Reeß, et al.
Published: (2024-11-01)

Correlation between serum neurofilament light chain and short-term outcomes in patients with hypertensive intracerebral hemorrhage
by: Jun Zhou, et al.
Published: (2025-02-01)

Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context
by: Deborah R. Gustafson, et al.
Published: (2025-02-01)

Role of pattern and multifocal electroretinogram for macular evaluation in patients with multiple sclerosis treated with fingolimod
by: Randa H. Abdelgawad, et al.
Published: (2025-01-01)

Plastic harmful ingredients reduce the level of neurofilament light chain protein
by: Long Li, et al.
Published: (2025-01-01)

Association of serum neurofilament light chain with cognitive impairment: findings from the National Health and Nutrition Examination Survey
by: Tianjiao Meng, et al.
Published: (2025-01-01)

Neurofilament Light Chain Levels in Serum and Cerebrospinal Fluid Do Not Correlate with Survival Times in Patients with Prion Disease
by: Mika Shimamura, et al.
Published: (2024-12-01)

Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels
by: Zhikui Zhou, et al.
Published: (2025-01-01)

Serum Biomarkers in Transthyretin Amyloidosis: An Overview of Neurofilaments, Cardiac, Renal, and Gastrointestinal Involvement
by: Valeria Guglielmino, et al.
Published: (2025-01-01)

Neurofilament Light Chain Assessment in Type 2 Diabetic Patients with Distal Symmetrical Polyneuropathy
by: Israa Abdelmalik Salem, et al.
Published: (2025-01-01)

Clinical Characteristics of Early-Onset and Late-Onset Multiple Sclerosis in Patients from Lithuania
by: Emilija Šlajūtė, et al.
Published: (2025-01-01)

What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?
by: Nathan Angelo Lecaros Yap, et al.
Published: (2025-01-01)

Tumour Debulking for Esophageal Cancer - Thermal Modalities
by: David Fleischer
Published: (1992-01-01)

Coherence vortices by binary pinholes
by: Gautam Akanksha, et al.
Published: (2024-10-01)

Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014
by: Yan Wang, et al.
Published: (2025-01-01)

Length of Polarization-Correlation Based on Speckle Pattern for Optical Coherent Detection
by: Longkun Zhang, et al.
Published: (2024-01-01)

A domed window chamber for multi-modality optical imaging
by: Photini Rice, et al.
Published: (2024-11-01)

Cryptocurrency returns and cryptocurrency uncertainty: a time–frequency analysis
by: Abdollah Ah Mand
Published: (2025-01-01)

Biomarkers in scleroderma: Current status
by: Latika Gupta, et al.
Published: (2017-01-01)

Beyond Benign: A Case of Subependymal Giant Cell Astrocytomas Provoking Hydrocephalus in Tuberous Sclerosis Complex
by: Antonio Navarro-Ballester, et al.
Published: (2024-05-01)

Fatigue and associated factors in multiple sclerosis patients in Latvia
by: S. Šetlere, et al.
Published: (2018-03-01)

Optic neuritis and multiple sclerosis association
by: L. Matukynaitė, et al.
Published: (2020-09-01)

Cohésion, cohérence et digression dans le discours à dominante explicative : une perspective diachronique (de la fin du XIIIe au XVIe siècle)
by: Sabine Lehmann
Published: (2018-12-01)

Presenting a one-objective optimization model to determine the reliability of the components of a coherent system
by: Elham Basiri
Published: (2023-11-01)

Improving a Low Axial Resolution Due to Improper Wavelength Calibration in Spectral-Domain Optical Coherence Tomography
by: Mengsi Zhang, et al.
Published: (2024-01-01)

Examining vaccination-related adverse events in frequent neurodegenerative diseases
by: Shabnam Sodagari, et al.
Published: (2025-02-01)

Characteristics of TSPO expression in marmoset EAE
by: Irene Falk, et al.
Published: (2025-01-01)

The Effect of Sensorimotor Synchronization on Gait Spatiotemporal Parameters in Women with Multiple Sclerosis
by: Mozhgan Memarmoghadam, et al.
Published: (2024-11-01)