Temporal dynamics of offline transcranial ultrasound stimulation
Transcranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation modality, characterized by deep-brain accuracy and the capability to induce longer-lasting effects. However, most TUS datasets are underpowered, hampering efforts to identify TUS longevity and temporal dynamics. Th...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Current Research in Neurobiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665945X25000026 |
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| author | Cyril Atkinson-Clement David Howett Mohammad Alkhawashki James Ross Ben Slater Marilyn Gatica Fabien Balezeau Chencheng Zhang Jerome Sallet Chris Petkov Marcus Kaiser |
| author_facet | Cyril Atkinson-Clement David Howett Mohammad Alkhawashki James Ross Ben Slater Marilyn Gatica Fabien Balezeau Chencheng Zhang Jerome Sallet Chris Petkov Marcus Kaiser |
| author_sort | Cyril Atkinson-Clement |
| collection | DOAJ |
| description | Transcranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation modality, characterized by deep-brain accuracy and the capability to induce longer-lasting effects. However, most TUS datasets are underpowered, hampering efforts to identify TUS longevity and temporal dynamics. This primate case was studied awake with over 50 fMRI datasets, with and without left anterior hippocampus TUS. We therefore amassed the highest-powered TUS dataset to date required to reveal TUS longevity and dynamics. Most of the effects were found in the TUS region itself and alongside the default mode and sensorimotor networks. Seed-based functional connectivity exhibited a time-constrained alteration which dissipated ∼60 min post-TUS. Intrinsic activity measure and regional homogeneity displayed extended diffusivity and longer durations. This high-powered dataset allowed predicting TUS using pre-stimulation features that can now extend to modeling of individuals scanned less extensively. This case report reveals the diversity of TUS temporal dynamics to help to advance long-lasting human applications. |
| format | Article |
| id | doaj-art-ea87b0d1aa8d4f9bb239a779c6789544 |
| institution | DOAJ |
| issn | 2665-945X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Neurobiology |
| spelling | doaj-art-ea87b0d1aa8d4f9bb239a779c67895442025-08-20T03:20:56ZengElsevierCurrent Research in Neurobiology2665-945X2025-06-01810014810.1016/j.crneur.2025.100148Temporal dynamics of offline transcranial ultrasound stimulationCyril Atkinson-Clement0David Howett1Mohammad Alkhawashki2James Ross3Ben Slater4Marilyn Gatica5Fabien Balezeau6Chencheng Zhang7Jerome Sallet8Chris Petkov9Marcus Kaiser10Precision Imaging, School of Medicine, University of Nottingham, United Kingdom; Corresponding author.School of Psychological Science, University of Bristol, United KingdomPrecision Imaging, School of Medicine, University of Nottingham, United KingdomPrecision Imaging, School of Medicine, University of Nottingham, United KingdomBiosciences Institute, Newcastle University Medical School, United KingdomPrecision Imaging, School of Medicine, University of Nottingham, United Kingdom; NPLab, Network Science Institute, Northeastern University London, London, United KingdomBiosciences Institute, Newcastle University Medical School, United KingdomDepartment of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, ChinaWellcome Centre for Integrative Neuroimaging, Department of Experimental Psychology, University of Oxford, United Kingdom; Univ Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, FranceBiosciences Institute, Newcastle University Medical School, United Kingdom; Department of Neurosurgery, University of Iowa, USAPrecision Imaging, School of Medicine, University of Nottingham, United Kingdom; School of Computing Science, Newcastle University, United Kingdom; Rui Jin Hospital, Shanghai Jiao Tong University, Shanghai, ChinaTranscranial ultrasound stimulation (TUS) is a promising non-invasive neuromodulation modality, characterized by deep-brain accuracy and the capability to induce longer-lasting effects. However, most TUS datasets are underpowered, hampering efforts to identify TUS longevity and temporal dynamics. This primate case was studied awake with over 50 fMRI datasets, with and without left anterior hippocampus TUS. We therefore amassed the highest-powered TUS dataset to date required to reveal TUS longevity and dynamics. Most of the effects were found in the TUS region itself and alongside the default mode and sensorimotor networks. Seed-based functional connectivity exhibited a time-constrained alteration which dissipated ∼60 min post-TUS. Intrinsic activity measure and regional homogeneity displayed extended diffusivity and longer durations. This high-powered dataset allowed predicting TUS using pre-stimulation features that can now extend to modeling of individuals scanned less extensively. This case report reveals the diversity of TUS temporal dynamics to help to advance long-lasting human applications.http://www.sciencedirect.com/science/article/pii/S2665945X25000026Ultrasound neuromodulationSeed-based connectivityfALFFReHo |
| spellingShingle | Cyril Atkinson-Clement David Howett Mohammad Alkhawashki James Ross Ben Slater Marilyn Gatica Fabien Balezeau Chencheng Zhang Jerome Sallet Chris Petkov Marcus Kaiser Temporal dynamics of offline transcranial ultrasound stimulation Current Research in Neurobiology Ultrasound neuromodulation Seed-based connectivity fALFF ReHo |
| title | Temporal dynamics of offline transcranial ultrasound stimulation |
| title_full | Temporal dynamics of offline transcranial ultrasound stimulation |
| title_fullStr | Temporal dynamics of offline transcranial ultrasound stimulation |
| title_full_unstemmed | Temporal dynamics of offline transcranial ultrasound stimulation |
| title_short | Temporal dynamics of offline transcranial ultrasound stimulation |
| title_sort | temporal dynamics of offline transcranial ultrasound stimulation |
| topic | Ultrasound neuromodulation Seed-based connectivity fALFF ReHo |
| url | http://www.sciencedirect.com/science/article/pii/S2665945X25000026 |
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