Hypomethylation of the p53 and p16 suppressor genes in cellular aging
Protein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the pr...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2024-01-01
|
| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/68/bioconf_geneticresources2024_01050.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850245509990580224 |
|---|---|
| author | Kadirova D.A. Mirhamidova P. Shakhmurova G.A. Alimova R.A. |
| author_facet | Kadirova D.A. Mirhamidova P. Shakhmurova G.A. Alimova R.A. |
| author_sort | Kadirova D.A. |
| collection | DOAJ |
| description | Protein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the promoter region of the p53 and p16 suppressor genes occurs during aging; the DNA hypomethylation is explained by the possible age-related decrease in the content of CH3-groups donor (S-adenosyl monophosphate) in the cell, and by the activity of DNA methyltransferases. |
| format | Article |
| id | doaj-art-ea876fc60e654232b0bc4c741e1a6669 |
| institution | OA Journals |
| issn | 2117-4458 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-ea876fc60e654232b0bc4c741e1a66692025-08-20T01:59:26ZengEDP SciencesBIO Web of Conferences2117-44582024-01-011490105010.1051/bioconf/202414901050bioconf_geneticresources2024_01050Hypomethylation of the p53 and p16 suppressor genes in cellular agingKadirova D.A.0Mirhamidova P.1Shakhmurova G.A.2Alimova R.A.3Institute of Biophysics And Biochemistry at the National University of Uzbekistan Named after M.Ulugbek in TashkentTashkent State Pedagogical University named after NizamiTashkent State Pedagogical University named after NizamiTashkent State Agrarian UniversityProtein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the promoter region of the p53 and p16 suppressor genes occurs during aging; the DNA hypomethylation is explained by the possible age-related decrease in the content of CH3-groups donor (S-adenosyl monophosphate) in the cell, and by the activity of DNA methyltransferases.https://www.bio-conferences.org/articles/bioconf/pdf/2024/68/bioconf_geneticresources2024_01050.pdf |
| spellingShingle | Kadirova D.A. Mirhamidova P. Shakhmurova G.A. Alimova R.A. Hypomethylation of the p53 and p16 suppressor genes in cellular aging BIO Web of Conferences |
| title | Hypomethylation of the p53 and p16 suppressor genes in cellular aging |
| title_full | Hypomethylation of the p53 and p16 suppressor genes in cellular aging |
| title_fullStr | Hypomethylation of the p53 and p16 suppressor genes in cellular aging |
| title_full_unstemmed | Hypomethylation of the p53 and p16 suppressor genes in cellular aging |
| title_short | Hypomethylation of the p53 and p16 suppressor genes in cellular aging |
| title_sort | hypomethylation of the p53 and p16 suppressor genes in cellular aging |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/68/bioconf_geneticresources2024_01050.pdf |
| work_keys_str_mv | AT kadirovada hypomethylationofthep53andp16suppressorgenesincellularaging AT mirhamidovap hypomethylationofthep53andp16suppressorgenesincellularaging AT shakhmurovaga hypomethylationofthep53andp16suppressorgenesincellularaging AT alimovara hypomethylationofthep53andp16suppressorgenesincellularaging |