Proofreading mechanism for colloidal self-assembly
Designing components that can robustly self-assemble into structures with biological complexity is a grand challenge for material science. Proofreading and error correction is required to improve assembly yield beyond equilibrium limits, using energy to avoid kinetic traps in the energy landscape. H...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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American Physical Society
2024-12-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.6.L042057 |
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| _version_ | 1850257931082137600 |
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| author | Qian-Ze Zhu Chrisy Xiyu Du Ella M. King Michael P. Brenner |
| author_facet | Qian-Ze Zhu Chrisy Xiyu Du Ella M. King Michael P. Brenner |
| author_sort | Qian-Ze Zhu |
| collection | DOAJ |
| description | Designing components that can robustly self-assemble into structures with biological complexity is a grand challenge for material science. Proofreading and error correction is required to improve assembly yield beyond equilibrium limits, using energy to avoid kinetic traps in the energy landscape. Here, we introduce an explicit two-staged proofreading scheme for patchy particle colloidal assemblies that substantially improves assembly yield and robustness. The first stage implements local rules whereby particles increase their binding strengths when they detect a local environment corresponding to a desired target. The second stage corrects remaining errors, adding a reverse pathway inspired by kinetic proofreading. The scheme shows significant yield improvements, eliminating kinetic traps, giving a much broader temperature range with high yield. Additionally, the scheme is robust against quenched disorder in the components. Our findings illuminate a pathway for advancing the programmable design of synthetic living materials, potentially fostering the synthesis of novel biological materials and functional behaviors. |
| format | Article |
| id | doaj-art-ea8718c6b52f401781c8ace34ef79411 |
| institution | OA Journals |
| issn | 2643-1564 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj-art-ea8718c6b52f401781c8ace34ef794112025-08-20T01:56:17ZengAmerican Physical SocietyPhysical Review Research2643-15642024-12-0164L04205710.1103/PhysRevResearch.6.L042057Proofreading mechanism for colloidal self-assemblyQian-Ze ZhuChrisy Xiyu DuElla M. KingMichael P. BrennerDesigning components that can robustly self-assemble into structures with biological complexity is a grand challenge for material science. Proofreading and error correction is required to improve assembly yield beyond equilibrium limits, using energy to avoid kinetic traps in the energy landscape. Here, we introduce an explicit two-staged proofreading scheme for patchy particle colloidal assemblies that substantially improves assembly yield and robustness. The first stage implements local rules whereby particles increase their binding strengths when they detect a local environment corresponding to a desired target. The second stage corrects remaining errors, adding a reverse pathway inspired by kinetic proofreading. The scheme shows significant yield improvements, eliminating kinetic traps, giving a much broader temperature range with high yield. Additionally, the scheme is robust against quenched disorder in the components. Our findings illuminate a pathway for advancing the programmable design of synthetic living materials, potentially fostering the synthesis of novel biological materials and functional behaviors.http://doi.org/10.1103/PhysRevResearch.6.L042057 |
| spellingShingle | Qian-Ze Zhu Chrisy Xiyu Du Ella M. King Michael P. Brenner Proofreading mechanism for colloidal self-assembly Physical Review Research |
| title | Proofreading mechanism for colloidal self-assembly |
| title_full | Proofreading mechanism for colloidal self-assembly |
| title_fullStr | Proofreading mechanism for colloidal self-assembly |
| title_full_unstemmed | Proofreading mechanism for colloidal self-assembly |
| title_short | Proofreading mechanism for colloidal self-assembly |
| title_sort | proofreading mechanism for colloidal self assembly |
| url | http://doi.org/10.1103/PhysRevResearch.6.L042057 |
| work_keys_str_mv | AT qianzezhu proofreadingmechanismforcolloidalselfassembly AT chrisyxiyudu proofreadingmechanismforcolloidalselfassembly AT ellamking proofreadingmechanismforcolloidalselfassembly AT michaelpbrenner proofreadingmechanismforcolloidalselfassembly |