Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities
Abstract. The production of high-quality oocytes requires precisely orchestrated intercellular communication. Extracellular vesicles (EVs) are cell-derived nanoparticles that play a vital role in the transfer of bioactive molecules, which has gained much attention in the field of diagnosis and treat...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-05-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003578 |
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| author | Zhongyu Zhao Yinrui Sun Renhao Guo Junzhi Liang Wanlin Dai Yutao Jiang Yafan Yu Yuexin Yu Lixia He Da Li Yanjie Yin |
| author_facet | Zhongyu Zhao Yinrui Sun Renhao Guo Junzhi Liang Wanlin Dai Yutao Jiang Yafan Yu Yuexin Yu Lixia He Da Li Yanjie Yin |
| author_sort | Zhongyu Zhao |
| collection | DOAJ |
| description | Abstract. The production of high-quality oocytes requires precisely orchestrated intercellular communication. Extracellular vesicles (EVs) are cell-derived nanoparticles that play a vital role in the transfer of bioactive molecules, which has gained much attention in the field of diagnosis and treatment. Over the past ten years, the participation of EVs in the reproductive processes of oocytes has been broadly studied and has shown great potential for elucidating the intricacies of female reproductive health. This review provides an extensive discussion of the influence of EVs on oocytes, emphasizing their involvement in normal physiology and altered cargo under pathological conditions. In addition, the positive impact of therapeutic EVs on oocyte quality and their role in alleviating ovarian pathological conditions are summarized. |
| format | Article |
| id | doaj-art-ea857a910fb14999821900939bdd78e2 |
| institution | OA Journals |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-ea857a910fb14999821900939bdd78e22025-08-20T01:50:21ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-05-0113891050106010.1097/CM9.0000000000003578202505050-00006Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunitiesZhongyu Zhao0Yinrui Sun1Renhao Guo2Junzhi Liang3Wanlin Dai4Yutao Jiang5Yafan Yu6Yuexin Yu7Lixia He8Da Li9Yanjie Yin1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China2 Department of Obstetrics and Gynecology, the Second Hospital of Dalian Medical University, Dalian, Liaoning 116021, China1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China3 The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, China4 Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning 110003, China1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, China1 Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, ChinaAbstract. The production of high-quality oocytes requires precisely orchestrated intercellular communication. Extracellular vesicles (EVs) are cell-derived nanoparticles that play a vital role in the transfer of bioactive molecules, which has gained much attention in the field of diagnosis and treatment. Over the past ten years, the participation of EVs in the reproductive processes of oocytes has been broadly studied and has shown great potential for elucidating the intricacies of female reproductive health. This review provides an extensive discussion of the influence of EVs on oocytes, emphasizing their involvement in normal physiology and altered cargo under pathological conditions. In addition, the positive impact of therapeutic EVs on oocyte quality and their role in alleviating ovarian pathological conditions are summarized.http://journals.lww.com/10.1097/CM9.0000000000003578 |
| spellingShingle | Zhongyu Zhao Yinrui Sun Renhao Guo Junzhi Liang Wanlin Dai Yutao Jiang Yafan Yu Yuexin Yu Lixia He Da Li Yanjie Yin Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities Chinese Medical Journal |
| title | Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities |
| title_full | Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities |
| title_fullStr | Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities |
| title_full_unstemmed | Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities |
| title_short | Extracellular vesicles: Roles in oocytes and emerging therapeutic opportunities |
| title_sort | extracellular vesicles roles in oocytes and emerging therapeutic opportunities |
| url | http://journals.lww.com/10.1097/CM9.0000000000003578 |
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