Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment
The oral thrush due to biofilms of Candida species is a common infection for the oral cavity of cancer patients undergoing chemotherapy, leading to oral infections. These biofilms, composed of Candida organisms, pose challenges in terms of diagnosis and treatment due to their increased resistance an...
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QAASPA Publisher
2023-06-01
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| Series: | BioMed Target Journal |
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| Online Access: | https://qaaspa.com/index.php/bmtj/article/view/4 |
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| author | Karzan Abdulmuhsin Mohammad Raya Kh. Yashooa Suhad Asad Mustafa |
| author_facet | Karzan Abdulmuhsin Mohammad Raya Kh. Yashooa Suhad Asad Mustafa |
| author_sort | Karzan Abdulmuhsin Mohammad |
| collection | DOAJ |
| description | The oral thrush due to biofilms of Candida species is a common infection for the oral cavity of cancer patients undergoing chemotherapy, leading to oral infections. These biofilms, composed of Candida organisms, pose challenges in terms of diagnosis and treatment due to their increased resistance and ability to persist in the oral environment. This study aimed to determine the frequency of Candida species biofilm colonization in the oral cavity of pediatric cancer patients receiving chemotherapy. By examining the incidence of Candida sp. biofilms, this research provides valuable insights into the oral health challenges specific to children with cancer, emphasizing the need for targeted preventive and management strategies to address these infections effectively. In this study, a total of 100 oral cavity swabs were collected, with 50 swabs obtained from cancer patients undergoing chemotherapy and suspected to have oral candidiasis, and the other 50 swabs collected from non-cancer healthy individuals serving as control. All swabs were cultured on Sabouraud Dextrose agar (SDA) media, followed by microscopic examination of positive samples. The API identification candida system was utilized for the identification of Candida species, along with the implementation of biochemical tests to further study the characteristics of the identified species.The findings demonstrated that out of the 50 cancer patients, approximately 47% (23 patients) exhibited positive yeast growth on SDA agar. Among the 50 non-cancer control cases, approximately 30% (15 cases) showed positive growth on SDA agar. Furthermore, using the API candida system, we confirmed the presence of candida species in 25 cases. Candida albicans was identified as the most prevalent species, followed by Candida parapsilosis, Candida krusei, and Saccharomyces cerevisiae, which were detected less frequently.
In conclusion, there were a significant increase in Candida species among cancer patients undergoing chemotherapy treatment in comparison to non-cancer control individuals. This finding highlights the impact of chemotherapy on the prevalence of Candida infections in cancer patients, emphasizing the need for heightened attention and appropriate management strategies in this vulnerable population. |
| format | Article |
| id | doaj-art-ea846c63be484c8982454bfbeccb8845 |
| institution | Kabale University |
| issn | 2960-1428 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | QAASPA Publisher |
| record_format | Article |
| series | BioMed Target Journal |
| spelling | doaj-art-ea846c63be484c8982454bfbeccb88452025-01-10T21:54:26ZengQAASPA PublisherBioMed Target Journal2960-14282023-06-0111182310.59786/bmtj.1144Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy TreatmentKarzan Abdulmuhsin Mohammad0https://orcid.org/0000-0003-1631-5675Raya Kh. Yashooa1https://orcid.org/0000-0002-9886-9868Suhad Asad Mustafa2https://orcid.org/0000-0002-6774-2979General Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil, 44001, IraqGeneral Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil, 44001, IraqGeneral Directorate of Scientific Research Center, Salahaddin University-Erbil, Erbil, 44001, IraqThe oral thrush due to biofilms of Candida species is a common infection for the oral cavity of cancer patients undergoing chemotherapy, leading to oral infections. These biofilms, composed of Candida organisms, pose challenges in terms of diagnosis and treatment due to their increased resistance and ability to persist in the oral environment. This study aimed to determine the frequency of Candida species biofilm colonization in the oral cavity of pediatric cancer patients receiving chemotherapy. By examining the incidence of Candida sp. biofilms, this research provides valuable insights into the oral health challenges specific to children with cancer, emphasizing the need for targeted preventive and management strategies to address these infections effectively. In this study, a total of 100 oral cavity swabs were collected, with 50 swabs obtained from cancer patients undergoing chemotherapy and suspected to have oral candidiasis, and the other 50 swabs collected from non-cancer healthy individuals serving as control. All swabs were cultured on Sabouraud Dextrose agar (SDA) media, followed by microscopic examination of positive samples. The API identification candida system was utilized for the identification of Candida species, along with the implementation of biochemical tests to further study the characteristics of the identified species.The findings demonstrated that out of the 50 cancer patients, approximately 47% (23 patients) exhibited positive yeast growth on SDA agar. Among the 50 non-cancer control cases, approximately 30% (15 cases) showed positive growth on SDA agar. Furthermore, using the API candida system, we confirmed the presence of candida species in 25 cases. Candida albicans was identified as the most prevalent species, followed by Candida parapsilosis, Candida krusei, and Saccharomyces cerevisiae, which were detected less frequently. In conclusion, there were a significant increase in Candida species among cancer patients undergoing chemotherapy treatment in comparison to non-cancer control individuals. This finding highlights the impact of chemotherapy on the prevalence of Candida infections in cancer patients, emphasizing the need for heightened attention and appropriate management strategies in this vulnerable population.https://qaaspa.com/index.php/bmtj/article/view/4oral candidiasisfungalcandida sp.biofilmscancer |
| spellingShingle | Karzan Abdulmuhsin Mohammad Raya Kh. Yashooa Suhad Asad Mustafa Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment BioMed Target Journal oral candidiasis fungal candida sp. biofilms cancer |
| title | Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment |
| title_full | Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment |
| title_fullStr | Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment |
| title_full_unstemmed | Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment |
| title_short | Incidence of Candida Species Biofilms in Pediatric Cancer Patients Undergoing Chemotherapy Treatment |
| title_sort | incidence of candida species biofilms in pediatric cancer patients undergoing chemotherapy treatment |
| topic | oral candidiasis fungal candida sp. biofilms cancer |
| url | https://qaaspa.com/index.php/bmtj/article/view/4 |
| work_keys_str_mv | AT karzanabdulmuhsinmohammad incidenceofcandidaspeciesbiofilmsinpediatriccancerpatientsundergoingchemotherapytreatment AT rayakhyashooa incidenceofcandidaspeciesbiofilmsinpediatriccancerpatientsundergoingchemotherapytreatment AT suhadasadmustafa incidenceofcandidaspeciesbiofilmsinpediatriccancerpatientsundergoingchemotherapytreatment |