Inactivation of SARS-CoV-2 at acidic pH is driven by partial unfolding of spike

Inactivation of SARS-CoV-2 at acidic pH is driven by partial unfolding of spike

Abstract SARS-CoV-2, the causative agent of COVID-19, is predominantly transmitted by respiratory aerosol and contaminated surfaces. Recent studies demonstrated that aerosols can become acidic, and acidification has been proposed as decontamination method. Here, we investigate how SARS-CoV-2 reacts...

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Main Authors: Irina Glas, Liv Zimmermann, Beiping Luo, Marie O. Pohl, Antoni G. Wrobel, Aline Schaub, Liviana K. Klein, Shannon C. David, Elisabeth Gaggioli, Nir Bluvshtein, Michael Huber, Athanasios Nenes, Ulrich K. Krieger, Thomas Peter, Tamar Kohn, Petr Chlanda, Silke Stertz
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08514-w
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