GliaTrap is a biodegradable, non-swelling and non-inflammatory hydrogel with tuned release of CXCL12 to attract migrating glioblastoma cells

GliaTrap is a biodegradable, non-swelling and non-inflammatory hydrogel with tuned release of CXCL12 to attract migrating glioblastoma cells

Abstract A significant factor in relapse and dismal prognosis of glioblastoma is the migrating glioblastoma cells, which diffuse away from the tumor mass into the brain parenchyma. Post-resection application of biomaterials to deliver cytotoxic agents against the invading glioblastoma cells has rece...

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Bibliographic Details
Main Authors: Yusuke Suita, Saradha Miriyala, Deniz Merih-Toruner, Mattia Pizzagalli, Owen P. Leary, Weizhou Yue, Lingxiao Xie, Blessing Akobundu, Nathan Pertsch, Andras Fiser, Eduardo Fajardo, Jie Shen, Nikos Tapinos
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-02977-x
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