Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population
Background: Accounting for dementia risk factors is essential in identifying people who would benefit most from intervention programs. The CAIDE dementia risk score is commonly applied, but its link to brain function remains unclear. This study aims to determine whether the variation in this score i...
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MDPI AG
2024-11-01
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| Series: | Brain Sciences |
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| author | Alice Rodrigues Manuel Pedro Ribeiro Gabriel Silva Pedro Miguel Rodrigues Maria Vânia Silva Nunes |
| author_facet | Alice Rodrigues Manuel Pedro Ribeiro Gabriel Silva Pedro Miguel Rodrigues Maria Vânia Silva Nunes |
| author_sort | Alice Rodrigues Manuel |
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| description | Background: Accounting for dementia risk factors is essential in identifying people who would benefit most from intervention programs. The CAIDE dementia risk score is commonly applied, but its link to brain function remains unclear. This study aims to determine whether the variation in this score is associated with neurophysiological changes and cognitive measures in normative individuals. Methods: The sample comprised 38 participants aged between 54 and 79 (M = 67.05; SD = 6.02). Data were collected using paper-and-pencil tests and electroencephalogram (EEG) recordings in the resting state, channels FP1 and FP2. The EEG signals were analyzed using Power Spectral Density (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>P</mi><mi>S</mi><mi>D</mi></mrow></semantics></math></inline-formula>)-based features. Results: The CAIDE score is positively correlated with the relative power activation of the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>θ</mi></semantics></math></inline-formula> band and negatively correlated with the MMSE cognitive test score, and MMSE variations align with those found in distributions of EEG-extracted <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>P</mi><mi>S</mi><mi>D</mi></mrow></semantics></math></inline-formula>-based features. Conclusions: The findings suggest that CAIDE scores can identify individuals without noticeable cognitive changes who already exhibit brain activity similar to that seen in people with dementia. They also contribute to the convergent validity between CAIDE and the risk of cognitive decline. This underscores the importance of early monitoring of these factors to reduce the incidence of dementia. |
| format | Article |
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| institution | OA Journals |
| issn | 2076-3425 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-ea7ff414a02048e98f4ece5b2bb08d722025-08-20T02:28:11ZengMDPI AGBrain Sciences2076-34252024-11-011411112010.3390/brainsci14111120Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy PopulationAlice Rodrigues Manuel0Pedro Ribeiro1Gabriel Silva2Pedro Miguel Rodrigues3Maria Vânia Silva Nunes4Faculdade de Ciências da Saúde e Enfermagem, Universidade Católica Portuguesa, Rua Palma de Cima, 1649-023 Lisboa, PortugalCBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalCBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalCBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalFaculdade de Ciências da Saúde e Enfermagem, Universidade Católica Portuguesa, Rua Palma de Cima, 1649-023 Lisboa, PortugalBackground: Accounting for dementia risk factors is essential in identifying people who would benefit most from intervention programs. The CAIDE dementia risk score is commonly applied, but its link to brain function remains unclear. This study aims to determine whether the variation in this score is associated with neurophysiological changes and cognitive measures in normative individuals. Methods: The sample comprised 38 participants aged between 54 and 79 (M = 67.05; SD = 6.02). Data were collected using paper-and-pencil tests and electroencephalogram (EEG) recordings in the resting state, channels FP1 and FP2. The EEG signals were analyzed using Power Spectral Density (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>P</mi><mi>S</mi><mi>D</mi></mrow></semantics></math></inline-formula>)-based features. Results: The CAIDE score is positively correlated with the relative power activation of the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>θ</mi></semantics></math></inline-formula> band and negatively correlated with the MMSE cognitive test score, and MMSE variations align with those found in distributions of EEG-extracted <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>P</mi><mi>S</mi><mi>D</mi></mrow></semantics></math></inline-formula>-based features. Conclusions: The findings suggest that CAIDE scores can identify individuals without noticeable cognitive changes who already exhibit brain activity similar to that seen in people with dementia. They also contribute to the convergent validity between CAIDE and the risk of cognitive decline. This underscores the importance of early monitoring of these factors to reduce the incidence of dementia.https://www.mdpi.com/2076-3425/14/11/1120CAIDEagingrisk of dementiaelectroencephalogramdeceleration effectcorrelation analysis |
| spellingShingle | Alice Rodrigues Manuel Pedro Ribeiro Gabriel Silva Pedro Miguel Rodrigues Maria Vânia Silva Nunes Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population Brain Sciences CAIDE aging risk of dementia electroencephalogram deceleration effect correlation analysis |
| title | Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population |
| title_full | Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population |
| title_fullStr | Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population |
| title_full_unstemmed | Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population |
| title_short | Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population |
| title_sort | exploring the relationship between caide dementia risk and eeg signal activity in a healthy population |
| topic | CAIDE aging risk of dementia electroencephalogram deceleration effect correlation analysis |
| url | https://www.mdpi.com/2076-3425/14/11/1120 |
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