The Autoimmune Mechanism in Dengue Hemorrhagic Fever
The immune response of dengue fever/dengue hemorrhagic fever is a series of immunopathogenesis processes starting from viral infection to the target on monocytes and macrophages. It may consequently cause a cascade of viremia in the circulation that stimulates the afferent, efferent, and effector me...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2018-04-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/157 |
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| author | Soroy Lardo Marsetyawan HNE Soesatyo Juffrie Juffrie Sitti Rahmah Umniyati |
| author_facet | Soroy Lardo Marsetyawan HNE Soesatyo Juffrie Juffrie Sitti Rahmah Umniyati |
| author_sort | Soroy Lardo |
| collection | DOAJ |
| description | The immune response of dengue fever/dengue hemorrhagic fever is a series of immunopathogenesis processes starting from viral infection to the target on monocytes and macrophages. It may consequently cause a cascade of viremia in the circulation that stimulates the afferent, efferent, and effector mechanism by the interaction of the humoral and complement system. The cascade results in inflammatory substance that will affect capillary permeability and activate coagulation factors leading to further effects on endothelial level. The mechanism involving pathogenesis of DHF/DSS is still vague. So far, a theory of heterologous infection has been developed, which explains that on second infection, there is subneutralization that induce viral replication. The autoimmune mechanism development leads to the better understanding of DHF. It also explains the autoimmune response of the viral infection, which consists of molecular mimicry, bystander activation and viral persistence. The development of the autoimmune pathomechanism is related to the role of autoantibody and endothelial dysfunction that may have role in worsening DHF. |
| format | Article |
| id | doaj-art-ea7dde2994a144f2861e0908e0aa6d3f |
| institution | DOAJ |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2018-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-ea7dde2994a144f2861e0908e0aa6d3f2025-08-20T02:50:15ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322018-04-01501The Autoimmune Mechanism in Dengue Hemorrhagic FeverSoroy Lardo0Marsetyawan HNE Soesatyo1Juffrie Juffrie2Sitti Rahmah Umniyati3Department of Internal Medicine, Gatot Soebroto Central Army Hospital–Jakarta, IndonesiaDepartment of Histology and Cellular Biology, Faculty of Medicine, University of Gadjah Mada, Sardjito Central General Hospital, YogyakartaDepartment of Pediatrics, Faculty of Medicine, University of Gadjah mada, Sardjito Central General Hospital, YogyakartaDepartment of Parasitology, Faculty of Medicine, University of Gadjah Mada, YogyakartaThe immune response of dengue fever/dengue hemorrhagic fever is a series of immunopathogenesis processes starting from viral infection to the target on monocytes and macrophages. It may consequently cause a cascade of viremia in the circulation that stimulates the afferent, efferent, and effector mechanism by the interaction of the humoral and complement system. The cascade results in inflammatory substance that will affect capillary permeability and activate coagulation factors leading to further effects on endothelial level. The mechanism involving pathogenesis of DHF/DSS is still vague. So far, a theory of heterologous infection has been developed, which explains that on second infection, there is subneutralization that induce viral replication. The autoimmune mechanism development leads to the better understanding of DHF. It also explains the autoimmune response of the viral infection, which consists of molecular mimicry, bystander activation and viral persistence. The development of the autoimmune pathomechanism is related to the role of autoantibody and endothelial dysfunction that may have role in worsening DHF.https://www.actamedindones.org/index.php/ijim/article/view/157Autoimmunedenguehemorrhagic fever |
| spellingShingle | Soroy Lardo Marsetyawan HNE Soesatyo Juffrie Juffrie Sitti Rahmah Umniyati The Autoimmune Mechanism in Dengue Hemorrhagic Fever Acta Medica Indonesiana Autoimmune dengue hemorrhagic fever |
| title | The Autoimmune Mechanism in Dengue Hemorrhagic Fever |
| title_full | The Autoimmune Mechanism in Dengue Hemorrhagic Fever |
| title_fullStr | The Autoimmune Mechanism in Dengue Hemorrhagic Fever |
| title_full_unstemmed | The Autoimmune Mechanism in Dengue Hemorrhagic Fever |
| title_short | The Autoimmune Mechanism in Dengue Hemorrhagic Fever |
| title_sort | autoimmune mechanism in dengue hemorrhagic fever |
| topic | Autoimmune dengue hemorrhagic fever |
| url | https://www.actamedindones.org/index.php/ijim/article/view/157 |
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