Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport
Critically ill patients with severe hypoxemia are often treated in the intensive care unit (ICU) with inhaled nitric oxide (iNO). These patients are at higher risk when they require intrahospital transportation. In this study, we collected clinical and laboratory data from 221 patients who were hosp...
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6633210 |
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| author | Leonid Koyfman Omri Simchon Anna Koyfman Shoshana Mushaev Benjamin F. Gruenbaum Ron Gal Michael Friger Natan Arotsker Alexander Zlotnik Moti Klein Evgeni Brotfain |
| author_facet | Leonid Koyfman Omri Simchon Anna Koyfman Shoshana Mushaev Benjamin F. Gruenbaum Ron Gal Michael Friger Natan Arotsker Alexander Zlotnik Moti Klein Evgeni Brotfain |
| author_sort | Leonid Koyfman |
| collection | DOAJ |
| description | Critically ill patients with severe hypoxemia are often treated in the intensive care unit (ICU) with inhaled nitric oxide (iNO). These patients are at higher risk when they require intrahospital transportation. In this study, we collected clinical and laboratory data from 221 patients who were hospitalized in the general ICU and treated with iNO at Soroka Medical Center, Israel, between January 2010 and December 2019. We retrospectively compared the 65 patients who received iNO during intrahospital transportation to the 156 patients who received iNO without transportation. Among critically ill patients who were transported while being administered iNO, only one patient had an adverse event (atrial fibrillation) on transport. We found that maximal iNO dosage during ICU stay, duration of mechanical ventilation, and percent of vasopressor support were the only independent risk factors for ICU mortality in both study groups. No difference in primary outcome of ICU mortality rate was found between the critically ill patients treated with iNO during intrahospital transportation and those who were treated with iNO but not transported during the ICU stay. We anticipate that this study will advise clinical decision-making in the ICU, especially when treating patients who are administered iNO. |
| format | Article |
| id | doaj-art-ea77f45b839b4fda91d9a1908fb29880 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-ea77f45b839b4fda91d9a1908fb298802025-02-03T01:10:53ZengWileyCritical Care Research and Practice2090-13052090-13132021-01-01202110.1155/2021/66332106633210Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital TransportLeonid Koyfman0Omri Simchon1Anna Koyfman2Shoshana Mushaev3Benjamin F. Gruenbaum4Ron Gal5Michael Friger6Natan Arotsker7Alexander Zlotnik8Moti Klein9Evgeni Brotfain10Department of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Radiology, Meir Medical Center, Kfar Saba, IsraelDepartment of Internal Medicine, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USADepartment of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelDepartment of Anesthesiology and Critical Care, General Intensive Care Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, IsraelCritically ill patients with severe hypoxemia are often treated in the intensive care unit (ICU) with inhaled nitric oxide (iNO). These patients are at higher risk when they require intrahospital transportation. In this study, we collected clinical and laboratory data from 221 patients who were hospitalized in the general ICU and treated with iNO at Soroka Medical Center, Israel, between January 2010 and December 2019. We retrospectively compared the 65 patients who received iNO during intrahospital transportation to the 156 patients who received iNO without transportation. Among critically ill patients who were transported while being administered iNO, only one patient had an adverse event (atrial fibrillation) on transport. We found that maximal iNO dosage during ICU stay, duration of mechanical ventilation, and percent of vasopressor support were the only independent risk factors for ICU mortality in both study groups. No difference in primary outcome of ICU mortality rate was found between the critically ill patients treated with iNO during intrahospital transportation and those who were treated with iNO but not transported during the ICU stay. We anticipate that this study will advise clinical decision-making in the ICU, especially when treating patients who are administered iNO.http://dx.doi.org/10.1155/2021/6633210 |
| spellingShingle | Leonid Koyfman Omri Simchon Anna Koyfman Shoshana Mushaev Benjamin F. Gruenbaum Ron Gal Michael Friger Natan Arotsker Alexander Zlotnik Moti Klein Evgeni Brotfain Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport Critical Care Research and Practice |
| title | Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport |
| title_full | Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport |
| title_fullStr | Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport |
| title_full_unstemmed | Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport |
| title_short | Clinical Outcomes of Critically Ill Patients Using Inhaled Nitric Oxide (iNO) during Intrahospital Transport |
| title_sort | clinical outcomes of critically ill patients using inhaled nitric oxide ino during intrahospital transport |
| url | http://dx.doi.org/10.1155/2021/6633210 |
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