NEDD4L contributes to ferroptosis and cell growth inhibition in esophageal squamous cell carcinoma by facilitating xCT ubiquitination

NEDD4L contributes to ferroptosis and cell growth inhibition in esophageal squamous cell carcinoma by facilitating xCT ubiquitination

Abstract The oncogene xCT plays an indispensable role in tumor growth by protecting cancer cells from oxidative stress and ferroptosis. Emerging evidence indicated xCT function is tightly controlled by posttranslational modifications, especially ubiquitination. However, it still remains unclear what...

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Main Authors: Zhen Chen, Weilong Wang, Jinghan Hou, Can Gao, Meili Song, Zijun Zhao, Ruirui Guan, Jingsheng Chen, Huicheng Wu, Siti Razila Abdul Razak, Tao Han, Junbo Zhang, Lidong Wang, Nor Hazwani Ahmad, Xiumin Li
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02243-5
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