An Overview of the Impact of Statin Therapy on Cardiac Incident Risk
Statin therapy is a cornerstone in preventing and managing cardiovascular diseases, particularly in reducing the risk of cardiac incidents. This review presents a comprehensive overview of the impact of statin therapy on cardiac incident risk, examining its efficacy in primary and secondary prevent...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58289 |
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| _version_ | 1823856468060798976 |
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| author | Urszula Świrk Aleksandra Paprocka Karolina Kalinowska Paulina Fijałek Jan Karczmarz Marika Gutowska Agnieszka Kosińska Wiktoria Belcarz Joanna Orzechowska Michał Orzechowski |
| author_facet | Urszula Świrk Aleksandra Paprocka Karolina Kalinowska Paulina Fijałek Jan Karczmarz Marika Gutowska Agnieszka Kosińska Wiktoria Belcarz Joanna Orzechowska Michał Orzechowski |
| author_sort | Urszula Świrk |
| collection | DOAJ |
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Statin therapy is a cornerstone in preventing and managing cardiovascular diseases, particularly in reducing the risk of cardiac incidents. This review presents a comprehensive overview of the impact of statin therapy on cardiac incident risk, examining its efficacy in primary and secondary prevention, the underlying mechanisms of action, associated adverse effects, and considerations for patient adherence. Evidence from large-scale randomized controlled trials and meta-analyses consistently demonstrates that statins significantly reduce the incidence of major cardiovascular events by lowering low-density lipoprotein (LDL) cholesterol levels and exerting pleiotropic effects like improving endothelial function and stabilizing atherosclerotic plaques. Although generally well-tolerated, statins may cause side effects, including muscle-related symptoms and a modest increase in the risk of type 2 diabetes. Patient adherence remains a critical factor in maximizing the therapeutic benefits of statin therapy.
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| format | Article |
| id | doaj-art-ea7551496e1a4886895151b80157ee41 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-ea7551496e1a4886895151b80157ee412025-02-12T08:26:11ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.58289An Overview of the Impact of Statin Therapy on Cardiac Incident RiskUrszula Świrk0https://orcid.org/0009-0007-6756-6016Aleksandra Paprocka1https://orcid.org/0009-0004-2082-5541Karolina Kalinowska2https://orcid.org/0009-0007-2657-7165Paulina Fijałek3https://orcid.org/0009-0000-2508-7059Jan Karczmarz4https://orcid.org/0009-0004-4960-4013Marika Gutowska5https://orcid.org/0009-0004-8297-5465Agnieszka Kosińska6https://orcid.org/0009-0008-3041-274XWiktoria Belcarz7https://orcid.org/0009-0003-3748-9380Joanna Orzechowska8https://orcid.org/0009-0005-6594-3717Michał Orzechowski9https://orcid.org/0009-0009-9315-1361Independent Public Health Care Facilities in Przasnysz, Dr. Wojciech Oczko Hospital Sadowa 9, 06-300 Przasnysz, Poland Jan Mikulicz-Radecki University Clinical Hospital, Borowska 213, 50-556 Wroclaw, PolandHealth Care Team of the District Hospital In Sochaczew, Batalionów Chłopskich 3/7, 96-500 Sochaczew, PolandSouthern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw, PolandSouthern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 Warsaw, PolandJózef Struś Multi-Specialist Municipal Hospital, Szwajcarska 3, 61-285, PoznańDistrict Hospital in Chrzanow, Topolowa 16, 32-500 Chrzanow, PolandMurcki Hospital Sp. z o.o., Sokołowskiego 2, 40-749 Katowice, Poland Jędrzej Śniadecki Specialist Hospital in Nowy Sącz Jędrzej Śniadecki Specialist Hospital in Nowy Sącz Statin therapy is a cornerstone in preventing and managing cardiovascular diseases, particularly in reducing the risk of cardiac incidents. This review presents a comprehensive overview of the impact of statin therapy on cardiac incident risk, examining its efficacy in primary and secondary prevention, the underlying mechanisms of action, associated adverse effects, and considerations for patient adherence. Evidence from large-scale randomized controlled trials and meta-analyses consistently demonstrates that statins significantly reduce the incidence of major cardiovascular events by lowering low-density lipoprotein (LDL) cholesterol levels and exerting pleiotropic effects like improving endothelial function and stabilizing atherosclerotic plaques. Although generally well-tolerated, statins may cause side effects, including muscle-related symptoms and a modest increase in the risk of type 2 diabetes. Patient adherence remains a critical factor in maximizing the therapeutic benefits of statin therapy. https://apcz.umk.pl/QS/article/view/58289Cardiovascular diseaseLDL cholesterolatherosclerosisstatins |
| spellingShingle | Urszula Świrk Aleksandra Paprocka Karolina Kalinowska Paulina Fijałek Jan Karczmarz Marika Gutowska Agnieszka Kosińska Wiktoria Belcarz Joanna Orzechowska Michał Orzechowski An Overview of the Impact of Statin Therapy on Cardiac Incident Risk Quality in Sport Cardiovascular disease LDL cholesterol atherosclerosis statins |
| title | An Overview of the Impact of Statin Therapy on Cardiac Incident Risk |
| title_full | An Overview of the Impact of Statin Therapy on Cardiac Incident Risk |
| title_fullStr | An Overview of the Impact of Statin Therapy on Cardiac Incident Risk |
| title_full_unstemmed | An Overview of the Impact of Statin Therapy on Cardiac Incident Risk |
| title_short | An Overview of the Impact of Statin Therapy on Cardiac Incident Risk |
| title_sort | overview of the impact of statin therapy on cardiac incident risk |
| topic | Cardiovascular disease LDL cholesterol atherosclerosis statins |
| url | https://apcz.umk.pl/QS/article/view/58289 |
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