Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection
Nephropathia epidemica (NE) caused by Puumala hantavirus (PUUV) is the most common hemorrhagic fever with renal syndrome (HFRS) in Europe. The infection activates immunological mechanisms that contribute to the pathogenesis and characteristics of the illness. In this study we measured cerebrospinal...
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/634632 |
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| author | Timo Hautala Terhi Partanen Tarja Sironen Saara-Mari Rajaniemi Nina Hautala Olli Vainio Olli Vapalahti Heikki Kauma Antti Vaheri |
| author_facet | Timo Hautala Terhi Partanen Tarja Sironen Saara-Mari Rajaniemi Nina Hautala Olli Vainio Olli Vapalahti Heikki Kauma Antti Vaheri |
| author_sort | Timo Hautala |
| collection | DOAJ |
| description | Nephropathia epidemica (NE) caused by Puumala hantavirus (PUUV) is the most common hemorrhagic fever with renal syndrome (HFRS) in Europe. The infection activates immunological mechanisms that contribute to the pathogenesis and characteristics of the illness. In this study we measured cerebrospinal fluid (CSF) neopterin concentration from 23 acute-phase NE patients. We collected data on kidney function, markers of tissue permeability, haemodynamic properties, blood cell count, length of hospitalisation, inflammatory parameters, and ophthalmological properties. The neopterin levels were elevated (>5.8 nmol/L) in 22 (96%) NE-patients (mean 45.8 nmol/L); these were especially high in patients with intrathecal PUUV-IgM production (mean 58.2 nmol/L, P=0.01) and those with elevated CSF protein concentrations (mean 63.6 nmol/L, P<0.05). We also observed a correlation between the neopterin and high plasma creatinine value (r=0.66, P=0.001), low blood thrombocyte count (r=-0.42, P<0.05), and markedly disturbed refractory properties of an eye (r=0.47, P<0.05). Length of hospitalisation correlated with the neopterin (r=0.42, P<0.05; male patients r=0.69, P<0.01). Patients with signs of tissue oedema and increased permeability also had high neopterin concentrations. These results reinforce the view that PUUV-HFRS is a general infection that affects the central nervous system and the blood-brain barrier. |
| format | Article |
| id | doaj-art-ea7403622970495789e62c9d6cb0a023 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ea7403622970495789e62c9d6cb0a0232025-02-03T01:30:56ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/634632634632Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus InfectionTimo Hautala0Terhi Partanen1Tarja Sironen2Saara-Mari Rajaniemi3Nina Hautala4Olli Vainio5Olli Vapalahti6Heikki Kauma7Antti Vaheri8Department of Internal Medicine, Oulu University Hospital, P.O. Box 20, 90029 Oulu, FinlandDepartment of Internal Medicine, Oulu University Hospital, P.O. Box 20, 90029 Oulu, FinlandDepartment of Virology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandInstitute of Diagnostics, Department of Medical Microbiology, University of Oulu, 90014 Oulu, FinlandDepartment of Ophthalmology, Oulu University Hospital, P.O. Box 21, 90029 Oulu, FinlandInstitute of Diagnostics, Department of Medical Microbiology, University of Oulu, 90014 Oulu, FinlandDepartment of Virology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandDepartment of Internal Medicine, Oulu University Hospital, P.O. Box 20, 90029 Oulu, FinlandDepartment of Virology, Haartman Institute, University of Helsinki, P.O. Box 21, 00014 Helsinki, FinlandNephropathia epidemica (NE) caused by Puumala hantavirus (PUUV) is the most common hemorrhagic fever with renal syndrome (HFRS) in Europe. The infection activates immunological mechanisms that contribute to the pathogenesis and characteristics of the illness. In this study we measured cerebrospinal fluid (CSF) neopterin concentration from 23 acute-phase NE patients. We collected data on kidney function, markers of tissue permeability, haemodynamic properties, blood cell count, length of hospitalisation, inflammatory parameters, and ophthalmological properties. The neopterin levels were elevated (>5.8 nmol/L) in 22 (96%) NE-patients (mean 45.8 nmol/L); these were especially high in patients with intrathecal PUUV-IgM production (mean 58.2 nmol/L, P=0.01) and those with elevated CSF protein concentrations (mean 63.6 nmol/L, P<0.05). We also observed a correlation between the neopterin and high plasma creatinine value (r=0.66, P=0.001), low blood thrombocyte count (r=-0.42, P<0.05), and markedly disturbed refractory properties of an eye (r=0.47, P<0.05). Length of hospitalisation correlated with the neopterin (r=0.42, P<0.05; male patients r=0.69, P<0.01). Patients with signs of tissue oedema and increased permeability also had high neopterin concentrations. These results reinforce the view that PUUV-HFRS is a general infection that affects the central nervous system and the blood-brain barrier.http://dx.doi.org/10.1155/2013/634632 |
| spellingShingle | Timo Hautala Terhi Partanen Tarja Sironen Saara-Mari Rajaniemi Nina Hautala Olli Vainio Olli Vapalahti Heikki Kauma Antti Vaheri Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection Clinical and Developmental Immunology |
| title | Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection |
| title_full | Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection |
| title_fullStr | Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection |
| title_full_unstemmed | Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection |
| title_short | Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection |
| title_sort | elevated cerebrospinal fluid neopterin concentration is associated with disease severity in acute puumala hantavirus infection |
| url | http://dx.doi.org/10.1155/2013/634632 |
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