Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis
BackgroundThe relationship between atopic dermatitis (AD) and lymphoma risk remains debate. This study systematically evaluates lymphoma risk in AD patients compared to non-AD individuals.MethodsA systematic search of PubMed, Embase, and the Cochrane Library (up to August 11, 2024) identified observ...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1580550/full |
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| author | Yingjie Tian Yingjie Tian Yujin Li Yujin Li Yujin Li Yang Chen Yang Chen Guoxing Yuan Bowen Peng Liang Su Jie Wu |
| author_facet | Yingjie Tian Yingjie Tian Yujin Li Yujin Li Yujin Li Yang Chen Yang Chen Guoxing Yuan Bowen Peng Liang Su Jie Wu |
| author_sort | Yingjie Tian |
| collection | DOAJ |
| description | BackgroundThe relationship between atopic dermatitis (AD) and lymphoma risk remains debate. This study systematically evaluates lymphoma risk in AD patients compared to non-AD individuals.MethodsA systematic search of PubMed, Embase, and the Cochrane Library (up to August 11, 2024) identified observational studies reporting lymphoma risk estimates for AD patients. Pooled odds ratios (OR) or relative risks (RR) with 95% CIs were calculated using a random-effects model (PROSPERO ID: CRD42024577019).ResultsOf 2,366 articles were screened, 13 studies met the inclusion criteria. AD was significantly associated with elevated lymphoma risk (OR = 2.56, 95% CI: 1.75–3.74, P < 0.001; RR = 1.23, 95% CI: 1.15–1.31, P < 0.001). The risk increased with AD severity, with severe cases showing the highest effect size (RR = 2.63; 95% CI: 1.94–3.58, P < 0.001; OR = 2.60; 95% CI: 1.71–3.96, P < 0.001). Subgroup analyses revealed high risks for Hodgkin lymphoma (HL) (RR = 1.54, 95% CI: 1.35–1.75, P < 0.001) and non-Hodgkin lymphoma (RR = 1.15, 95% CI: 1.04–1.28, P = 0.006). Notably, T-cell lymphoma (TCL) showed the highest risk (OR = 4.25; 95% CI: 1.94–9.33, P < 0.001). whereas no significant association was observed for B-cell lymphoma (OR = 1.07; 95% CI: 0.95–1.20, P = 0.271).ConclusionAD is significantly association with increased lymphoma risk, particularly HL, NHL and TCL. AD severity may amplify this risk. Future research is warranted to explore underlying mechanisms and address limitations in the current evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024577019. |
| format | Article |
| id | doaj-art-ea71d8d73fea4fb291570a8fbb2b35d2 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-ea71d8d73fea4fb291570a8fbb2b35d22025-08-20T03:10:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15805501580550Atopic dermatitis and lymphoma risk: a systematic review and meta-analysisYingjie Tian0Yingjie Tian1Yujin Li2Yujin Li3Yujin Li4Yang Chen5Yang Chen6Guoxing Yuan7Bowen Peng8Liang Su9Jie Wu10Department of Hematology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Hematology, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Provincial Clinical Medical Center for Blood Diseases and Thrombosis Prevention and Treatment, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaYunnan Provincial Key Laboratory of Innovative Application of Characteristic Chinese Materia Medica, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Pathology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDepartment of Pathology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, ChinaDepartment of Hematology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Hematology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Hematology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Hematology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBackgroundThe relationship between atopic dermatitis (AD) and lymphoma risk remains debate. This study systematically evaluates lymphoma risk in AD patients compared to non-AD individuals.MethodsA systematic search of PubMed, Embase, and the Cochrane Library (up to August 11, 2024) identified observational studies reporting lymphoma risk estimates for AD patients. Pooled odds ratios (OR) or relative risks (RR) with 95% CIs were calculated using a random-effects model (PROSPERO ID: CRD42024577019).ResultsOf 2,366 articles were screened, 13 studies met the inclusion criteria. AD was significantly associated with elevated lymphoma risk (OR = 2.56, 95% CI: 1.75–3.74, P < 0.001; RR = 1.23, 95% CI: 1.15–1.31, P < 0.001). The risk increased with AD severity, with severe cases showing the highest effect size (RR = 2.63; 95% CI: 1.94–3.58, P < 0.001; OR = 2.60; 95% CI: 1.71–3.96, P < 0.001). Subgroup analyses revealed high risks for Hodgkin lymphoma (HL) (RR = 1.54, 95% CI: 1.35–1.75, P < 0.001) and non-Hodgkin lymphoma (RR = 1.15, 95% CI: 1.04–1.28, P = 0.006). Notably, T-cell lymphoma (TCL) showed the highest risk (OR = 4.25; 95% CI: 1.94–9.33, P < 0.001). whereas no significant association was observed for B-cell lymphoma (OR = 1.07; 95% CI: 0.95–1.20, P = 0.271).ConclusionAD is significantly association with increased lymphoma risk, particularly HL, NHL and TCL. AD severity may amplify this risk. Future research is warranted to explore underlying mechanisms and address limitations in the current evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024577019.https://www.frontiersin.org/articles/10.3389/fonc.2025.1580550/fullatopic dermatitislymphomaT-cell lymphomasystematic reviewmeta-analysis |
| spellingShingle | Yingjie Tian Yingjie Tian Yujin Li Yujin Li Yujin Li Yang Chen Yang Chen Guoxing Yuan Bowen Peng Liang Su Jie Wu Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis Frontiers in Oncology atopic dermatitis lymphoma T-cell lymphoma systematic review meta-analysis |
| title | Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis |
| title_full | Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis |
| title_fullStr | Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis |
| title_full_unstemmed | Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis |
| title_short | Atopic dermatitis and lymphoma risk: a systematic review and meta-analysis |
| title_sort | atopic dermatitis and lymphoma risk a systematic review and meta analysis |
| topic | atopic dermatitis lymphoma T-cell lymphoma systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1580550/full |
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