Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis
Aim: The natural course of sarcoidosis is heterogeneous. There is no clear marker that can predict the course of this disease and its characteristics over months/years. We aimed to analyze our patients' data to identify a prediction parameter at admission.Methods: The patients with sarcoidosis...
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Alanya Alaaddin Keykubat University
2022-03-01
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| Series: | Acta Medica Alanya |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1809627 |
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| author | Deniz Çelik Sertan Bulut |
| author_facet | Deniz Çelik Sertan Bulut |
| author_sort | Deniz Çelik |
| collection | DOAJ |
| description | Aim: The natural course of sarcoidosis is heterogeneous. There is no clear marker that can predict the course of this disease and its characteristics over months/years. We aimed to analyze our patients' data to identify a prediction parameter at admission.Methods: The patients with sarcoidosis and followed-up between 01/01/2015 and 31/12/2020 comprised the study group. The patients were staged by a Scadding staging system. Improvement or deterioration in at least two of the clinical-laboratory-radiological parameters indicates regression, stable disease, progression, or relapse of sarcoidosis.Results: The study group comprised 4 cases (6.9%) defined as stage 0; 15 cases (25.86%) as stage 1; 39 cases (67.24%) were defined as stage 2. The mean age at diagnosis was 40.84±13.56 in stage 0 + stage 1 group, while it was 48.05±13.36 in the stage 2 group (p=0.06). 74.1% of the cases were women. The female/male ratio was found at 2.86. 57 out of 58 cases had a pathological diagnosis (EBUS TBNA). While PFTs values and DLCO were significantly lower at advanced stages but the same statistical significance was not identified between these values and the clinical course of the disease. As a result of the multivariate analysis, it was observed that only the presence of chest pain at admission affected the progression of the disease in the follow-up period.Conclusion: Sarcoidosis is a multi-systemic disease and there is no clear finding for predicting the poor prognosis of the disease. We conclude that chest pain symptom at admission is valuable predictive finding and can be used as a clue for the progression at follow-up. |
| format | Article |
| id | doaj-art-ea6eba75a27e4ebabd69b9949f365b88 |
| institution | OA Journals |
| issn | 2587-0319 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Alanya Alaaddin Keykubat University |
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| series | Acta Medica Alanya |
| spelling | doaj-art-ea6eba75a27e4ebabd69b9949f365b882025-08-20T02:19:02ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192022-03-0161344110.30565/medalanya.948632727Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of SarcoidosisDeniz Çelik0https://orcid.org/0000-0003-4634-205XSertan Bulut1https://orcid.org/0000-0003-1267-3440ALANYA ALAADDİN KEYKUBAT ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, GÖĞÜS HASTALIKLARI ANABİLİM DALISAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ATATÜRK GÖĞÜS HASTALIKLARI VE GÖĞÜS CERRAHİSİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, GÖĞÜS HASTALIKLARI ANABİLİM DALIAim: The natural course of sarcoidosis is heterogeneous. There is no clear marker that can predict the course of this disease and its characteristics over months/years. We aimed to analyze our patients' data to identify a prediction parameter at admission.Methods: The patients with sarcoidosis and followed-up between 01/01/2015 and 31/12/2020 comprised the study group. The patients were staged by a Scadding staging system. Improvement or deterioration in at least two of the clinical-laboratory-radiological parameters indicates regression, stable disease, progression, or relapse of sarcoidosis.Results: The study group comprised 4 cases (6.9%) defined as stage 0; 15 cases (25.86%) as stage 1; 39 cases (67.24%) were defined as stage 2. The mean age at diagnosis was 40.84±13.56 in stage 0 + stage 1 group, while it was 48.05±13.36 in the stage 2 group (p=0.06). 74.1% of the cases were women. The female/male ratio was found at 2.86. 57 out of 58 cases had a pathological diagnosis (EBUS TBNA). While PFTs values and DLCO were significantly lower at advanced stages but the same statistical significance was not identified between these values and the clinical course of the disease. As a result of the multivariate analysis, it was observed that only the presence of chest pain at admission affected the progression of the disease in the follow-up period.Conclusion: Sarcoidosis is a multi-systemic disease and there is no clear finding for predicting the poor prognosis of the disease. We conclude that chest pain symptom at admission is valuable predictive finding and can be used as a clue for the progression at follow-up.https://dergipark.org.tr/tr/download/article-file/1809627sarkoidozprognozprogresyonebus tbnasarcoidosisprognosisprogressionebus tbna |
| spellingShingle | Deniz Çelik Sertan Bulut Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis Acta Medica Alanya sarkoidoz prognoz progresyon ebus tbna sarcoidosis prognosis progression ebus tbna |
| title | Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis |
| title_full | Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis |
| title_fullStr | Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis |
| title_full_unstemmed | Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis |
| title_short | Effectiveness Of Clinical Parameters And Laboratory Values In Predicting The Clinical Course of Sarcoidosis |
| title_sort | effectiveness of clinical parameters and laboratory values in predicting the clinical course of sarcoidosis |
| topic | sarkoidoz prognoz progresyon ebus tbna sarcoidosis prognosis progression ebus tbna |
| url | https://dergipark.org.tr/tr/download/article-file/1809627 |
| work_keys_str_mv | AT denizcelik effectivenessofclinicalparametersandlaboratoryvaluesinpredictingtheclinicalcourseofsarcoidosis AT sertanbulut effectivenessofclinicalparametersandlaboratoryvaluesinpredictingtheclinicalcourseofsarcoidosis |