A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance
Platelets are a class of blood cells exfoliated from bone marrow megakaryocytes and important participants in the blood. Aggregation is a prominent part of the platelets involved in the hemostasis process, regulated by multiple signaling pathways. Abnormal platelet aggregation could lead to thrombos...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1537776/full |
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| author | Yi Hou Hong Li Luochen Zhu Yue Li Yue Zeng Tian Quan Zhangqiang Xiang Yue Zhang Yuan Bian Yuxun Wei |
| author_facet | Yi Hou Hong Li Luochen Zhu Yue Li Yue Zeng Tian Quan Zhangqiang Xiang Yue Zhang Yuan Bian Yuxun Wei |
| author_sort | Yi Hou |
| collection | DOAJ |
| description | Platelets are a class of blood cells exfoliated from bone marrow megakaryocytes and important participants in the blood. Aggregation is a prominent part of the platelets involved in the hemostasis process, regulated by multiple signaling pathways. Abnormal platelet aggregation could lead to thrombosis or hemorrhagic disorders, which is closely related to the abnormal expression of receptors inside and outside platelet cells and the mis-transmission of signaling factors. In recent years, natural compounds have been shown to regulate platelet aggregation on different levels, including platelet surface receptors, intracellular signaling factors, and release reaction from platelet secretory granules, due to their structiral characteristics. However, the anti-platelet aggregation mechanism of natural compounds is not comprehensive. Therefore, we have elaborated the main pathways that affect platelet aggregation in terms of the adenosine diphosphate (ADP), the levels of cAMP and cGMP, arachidonic acid (ARA) metabolism pathway, thrombin and collagen pathways in this paper. Particularly, we reviewed various natural compounds such as glycosides, coumarins, alkaloids, and acids that affect platelet aggregation mechanisms through these pathways. This review provides a reference for the application of natural compounds in the structural modification of platelet aggregation as well as in clinical studies. |
| format | Article |
| id | doaj-art-ea6d47a2e2c94f2693d8638f9a65e0ba |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-ea6d47a2e2c94f2693d8638f9a65e0ba2025-08-20T03:24:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15377761537776A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advanceYi Hou0Hong Li1Luochen Zhu2Yue Li3Yue Zeng4Tian Quan5Zhangqiang Xiang6Yue Zhang7Yuan Bian8Yuxun Wei9Pharmacy Department, Clinical Trial Institution, The People’s Hospital of Zhongjiang, Deyang, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, Nantong Tumor Hospital (Tumor Hospital Affiliated to Nantong University), Nantong, ChinaMolecular Urooncology Department of Urology Klinikum rechts der Isar Technical University of Munich Ismaningerstr, München, GermanyPharmacy Department, Clinical Trial Institution, The People’s Hospital of Zhongjiang, Deyang, ChinaPharmacy Department, Clinical Trial Institution, The People’s Hospital of Zhongjiang, Deyang, ChinaPhase 1 Clinical Trial Center, Deyang People’s Hospital, Deyang, ChinaPharmacy Department, Clinical Trial Institution, The People’s Hospital of Zhongjiang, Deyang, ChinaDepartment of Oncology, Xichang People’s Hospital, Xichang, ChinaPharmacy Department, Clinical Trial Institution, The People’s Hospital of Zhongjiang, Deyang, ChinaPlatelets are a class of blood cells exfoliated from bone marrow megakaryocytes and important participants in the blood. Aggregation is a prominent part of the platelets involved in the hemostasis process, regulated by multiple signaling pathways. Abnormal platelet aggregation could lead to thrombosis or hemorrhagic disorders, which is closely related to the abnormal expression of receptors inside and outside platelet cells and the mis-transmission of signaling factors. In recent years, natural compounds have been shown to regulate platelet aggregation on different levels, including platelet surface receptors, intracellular signaling factors, and release reaction from platelet secretory granules, due to their structiral characteristics. However, the anti-platelet aggregation mechanism of natural compounds is not comprehensive. Therefore, we have elaborated the main pathways that affect platelet aggregation in terms of the adenosine diphosphate (ADP), the levels of cAMP and cGMP, arachidonic acid (ARA) metabolism pathway, thrombin and collagen pathways in this paper. Particularly, we reviewed various natural compounds such as glycosides, coumarins, alkaloids, and acids that affect platelet aggregation mechanisms through these pathways. This review provides a reference for the application of natural compounds in the structural modification of platelet aggregation as well as in clinical studies.https://www.frontiersin.org/articles/10.3389/fphar.2025.1537776/fullplatelet aggregationplatelet activationnatural compoundsmolecular mechanismclinical trials |
| spellingShingle | Yi Hou Hong Li Luochen Zhu Yue Li Yue Zeng Tian Quan Zhangqiang Xiang Yue Zhang Yuan Bian Yuxun Wei A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance Frontiers in Pharmacology platelet aggregation platelet activation natural compounds molecular mechanism clinical trials |
| title | A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance |
| title_full | A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance |
| title_fullStr | A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance |
| title_full_unstemmed | A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance |
| title_short | A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance |
| title_sort | review of natural compounds to regulate platelet aggregation molecular mechanism and research advance |
| topic | platelet aggregation platelet activation natural compounds molecular mechanism clinical trials |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1537776/full |
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