Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice

Immunogenicity and cellular response of a herpes zoster virus gEgI fusion protein adjuvanted with CpG-emulsion in mice

Abstract Herpes zoster (HZ), commonly known as shingles, arises from the reactivation of the latent varicella-zoster virus (VZV) when VZV-specific cellular immunity declines below a critical threshold necessary for viral suppression. The current leading vaccine, Shingrix, which incorporates the adju...

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Bibliographic Details
Main Authors: Sibo Zhang, Yarong Zeng, Lingyan Cui, Yiwen Zhang, Tingting Chen, Wenhui Xue, Hong Wang, Hongjing Liu, Yuyun Zhang, Lin Chen, Lizhi Zhou, Yueting Xiong, Qingbing Zheng, Hai Yu, Tong Cheng, Jun Zhang, Ying Gu, Tingting Li, Ningshao Xia, Shaowei Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Varicella-zoster virus
HZ vaccine
Glycoprotein E
Glycoprotein I
Adjuvant
CpG-emulsion
Online Access:https://doi.org/10.1186/s12951-025-03423-w
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