Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors
Abstract The efficacy of many cancer nanocarriers has traditionally been attributed to enlarged tumor vasculature fenestrations, giving rise to the concept of the enhanced permeability and retention (EPR) effect. However, emerging evidence suggests that active biological processes, such as transcyto...
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| Main Authors: | Yanyan Liu, Qikai Wang, Zhenhan Feng, Mengmeng Qin, Zhenyu Zhang, Jinhong Jiang, Tongxiang Ren, Xiangsheng Liu, C. Jeffrey Brinker, Yuliang Zhao, Huan Meng |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61434-5 |
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