Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases
CD47 is an immune checkpoint widely regarded as a ‘don't eat me’ signal. CD47-based anti-cancer therapy has received considerable attention, with a significant number of clinical trials conducted. While anti-cancer therapies based on CD47 remain a focal point of interest among researchers, it i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383524004519 |
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| author | Wei-Qing Deng Zi-Han Ye Zhenghai Tang Xiao-Lei Zhang Jin-Jian Lu |
| author_facet | Wei-Qing Deng Zi-Han Ye Zhenghai Tang Xiao-Lei Zhang Jin-Jian Lu |
| author_sort | Wei-Qing Deng |
| collection | DOAJ |
| description | CD47 is an immune checkpoint widely regarded as a ‘don't eat me’ signal. CD47-based anti-cancer therapy has received considerable attention, with a significant number of clinical trials conducted. While anti-cancer therapies based on CD47 remain a focal point of interest among researchers, it is noteworthy that an increasing number of studies have found that CD47-based therapy ameliorated the pathological status of non-cancer diseases. This review aims to provide an overview of the recent progress in comprehending the role of CD47-based therapy in non-cancer diseases, including diseases of the circulatory system, nervous system, digestive system, and so on. Furthermore, we sought to delineate the promising mechanisms of CD47-based therapy in treating non-cancer diseases. Our findings suggest that CD47-based agents may exert their effect by regulating phagocytosis, regulating T cells, dendritic cells, and neutrophils, and regulating the secretion of cytokines and chemokines. Additionally, we put forward the orientation of further research to bring to light the potential of CD47 and its binding partners as a target in non-cancer diseases. |
| format | Article |
| id | doaj-art-ea64c46fcfd94a34a2d700333d1d3e35 |
| institution | DOAJ |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-ea64c46fcfd94a34a2d700333d1d3e352025-08-20T02:56:47ZengElsevierActa Pharmaceutica Sinica B2211-38352025-02-0115275779110.1016/j.apsb.2024.11.018Beyond cancer: The potential application of CD47-based therapy in non-cancer diseasesWei-Qing Deng0Zi-Han Ye1Zhenghai Tang2Xiao-Lei Zhang3Jin-Jian Lu4State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, ChinaDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macao 999078, ChinaNational-Local Joint Engineering Laboratory of Druggability and New Drug Evaluation, Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao 999078, China; MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao 999078, China; Corresponding author.CD47 is an immune checkpoint widely regarded as a ‘don't eat me’ signal. CD47-based anti-cancer therapy has received considerable attention, with a significant number of clinical trials conducted. While anti-cancer therapies based on CD47 remain a focal point of interest among researchers, it is noteworthy that an increasing number of studies have found that CD47-based therapy ameliorated the pathological status of non-cancer diseases. This review aims to provide an overview of the recent progress in comprehending the role of CD47-based therapy in non-cancer diseases, including diseases of the circulatory system, nervous system, digestive system, and so on. Furthermore, we sought to delineate the promising mechanisms of CD47-based therapy in treating non-cancer diseases. Our findings suggest that CD47-based agents may exert their effect by regulating phagocytosis, regulating T cells, dendritic cells, and neutrophils, and regulating the secretion of cytokines and chemokines. Additionally, we put forward the orientation of further research to bring to light the potential of CD47 and its binding partners as a target in non-cancer diseases.http://www.sciencedirect.com/science/article/pii/S2211383524004519CD47Non-cancer diseaseApplicationMechanismPhagocytosisClinical data |
| spellingShingle | Wei-Qing Deng Zi-Han Ye Zhenghai Tang Xiao-Lei Zhang Jin-Jian Lu Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases Acta Pharmaceutica Sinica B CD47 Non-cancer disease Application Mechanism Phagocytosis Clinical data |
| title | Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases |
| title_full | Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases |
| title_fullStr | Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases |
| title_full_unstemmed | Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases |
| title_short | Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases |
| title_sort | beyond cancer the potential application of cd47 based therapy in non cancer diseases |
| topic | CD47 Non-cancer disease Application Mechanism Phagocytosis Clinical data |
| url | http://www.sciencedirect.com/science/article/pii/S2211383524004519 |
| work_keys_str_mv | AT weiqingdeng beyondcancerthepotentialapplicationofcd47basedtherapyinnoncancerdiseases AT zihanye beyondcancerthepotentialapplicationofcd47basedtherapyinnoncancerdiseases AT zhenghaitang beyondcancerthepotentialapplicationofcd47basedtherapyinnoncancerdiseases AT xiaoleizhang beyondcancerthepotentialapplicationofcd47basedtherapyinnoncancerdiseases AT jinjianlu beyondcancerthepotentialapplicationofcd47basedtherapyinnoncancerdiseases |