Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

Abstract In this study, heterozygous expression of a common Parkinson-associated GBA1 variant, the L444P mutation, was found to exacerbate α-synuclein aggregation and spreading in a mouse model of Parkinson-like pathology targeting neurons of the medullary vagal system. These neurons were also shown...

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Bibliographic Details
Main Authors: Pietro La Vitola, Eva M. Szegö, Rita Pinto-Costa, Angela Rollar, Eugenia Harbachova, Anthony HV Schapira, Ayse Ulusoy, Donato A. Di Monte
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00842-8
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