Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet
Trimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation from TMA in liver. The TMA generation was influenced by diet, mainly due to the rich TMAO precursors in diet. However, it was...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-03-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250054 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849692567943249920 |
|---|---|
| author | Chengcheng Wang Xuefeng Duan Xiaoyue Li Jinyue Yang Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang |
| author_facet | Chengcheng Wang Xuefeng Duan Xiaoyue Li Jinyue Yang Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang |
| author_sort | Chengcheng Wang |
| collection | DOAJ |
| description | Trimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation from TMA in liver. The TMA generation was influenced by diet, mainly due to the rich TMAO precursors in diet. However, it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO. Here, the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA, respectively, in mice fed with carbohydrates, proteins and fats in different proportion and sources. The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA, and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver. The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO, the risk factor for atherosclerosis, which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis. |
| format | Article |
| id | doaj-art-ea56ca00f091489cae72707a9cc7b448 |
| institution | DOAJ |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-ea56ca00f091489cae72707a9cc7b4482025-08-20T03:20:39ZengTsinghua University PressFood Science and Human Wellness2213-45302024-03-0113264965810.26599/FSHW.2022.9250054Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the dietChengcheng Wang0Xuefeng Duan1Xiaoyue Li2Jinyue Yang3Changhu Xue4Teruyoshi Yanagita5Tiantian Zhang6Yuming Wang7College of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaLaboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, JapanCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, ChinaTrimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation from TMA in liver. The TMA generation was influenced by diet, mainly due to the rich TMAO precursors in diet. However, it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO. Here, the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA, respectively, in mice fed with carbohydrates, proteins and fats in different proportion and sources. The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA, and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver. The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO, the risk factor for atherosclerosis, which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis.https://www.sciopen.com/article/10.26599/FSHW.2022.9250054trimethylamine n-oxide (tmao)trimethylamine (tma)dietary compositionmacronutrientsgut microbiota |
| spellingShingle | Chengcheng Wang Xuefeng Duan Xiaoyue Li Jinyue Yang Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet Food Science and Human Wellness trimethylamine n-oxide (tmao) trimethylamine (tma) dietary composition macronutrients gut microbiota |
| title | Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet |
| title_full | Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet |
| title_fullStr | Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet |
| title_full_unstemmed | Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet |
| title_short | Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet |
| title_sort | trimethylamine n oxide generation process was influenced by the proportion and source of macronutrients in the diet |
| topic | trimethylamine n-oxide (tmao) trimethylamine (tma) dietary composition macronutrients gut microbiota |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250054 |
| work_keys_str_mv | AT chengchengwang trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT xuefengduan trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT xiaoyueli trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT jinyueyang trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT changhuxue trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT teruyoshiyanagita trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT tiantianzhang trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet AT yumingwang trimethylaminenoxidegenerationprocesswasinfluencedbytheproportionandsourceofmacronutrientsinthediet |