Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed
The epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/828264 |
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| _version_ | 1832553022255792128 |
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| author | Paul M. Peeters Emiel F. Wouters Niki L. Reynaert |
| author_facet | Paul M. Peeters Emiel F. Wouters Niki L. Reynaert |
| author_sort | Paul M. Peeters |
| collection | DOAJ |
| description | The epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors. Amongst these are a number of inflammasome sensor subtypes, which have been initially characterized in myeloid cells and described to be activated upon assembly into multiprotein complexes by microbial and environmental triggers. This review compiles a vast amount of literature that supports a pivotal role for inflammasomes in the various epithelial barriers of the human body as essential factors maintaining immune signaling and homeostasis. |
| format | Article |
| id | doaj-art-ea51ec09f8fb45218d9c57eb88e707dd |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ea51ec09f8fb45218d9c57eb88e707dd2025-02-03T05:57:09ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/828264828264Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling ReviewedPaul M. Peeters0Emiel F. Wouters1Niki L. Reynaert2Department of Respiratory Medicine, Nutrim School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, NetherlandsDepartment of Respiratory Medicine, Nutrim School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, NetherlandsDepartment of Respiratory Medicine, Nutrim School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, 6229 HX Maastricht, NetherlandsThe epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors. Amongst these are a number of inflammasome sensor subtypes, which have been initially characterized in myeloid cells and described to be activated upon assembly into multiprotein complexes by microbial and environmental triggers. This review compiles a vast amount of literature that supports a pivotal role for inflammasomes in the various epithelial barriers of the human body as essential factors maintaining immune signaling and homeostasis.http://dx.doi.org/10.1155/2015/828264 |
| spellingShingle | Paul M. Peeters Emiel F. Wouters Niki L. Reynaert Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed Journal of Immunology Research |
| title | Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed |
| title_full | Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed |
| title_fullStr | Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed |
| title_full_unstemmed | Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed |
| title_short | Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed |
| title_sort | immune homeostasis in epithelial cells evidence and role of inflammasome signaling reviewed |
| url | http://dx.doi.org/10.1155/2015/828264 |
| work_keys_str_mv | AT paulmpeeters immunehomeostasisinepithelialcellsevidenceandroleofinflammasomesignalingreviewed AT emielfwouters immunehomeostasisinepithelialcellsevidenceandroleofinflammasomesignalingreviewed AT nikilreynaert immunehomeostasisinepithelialcellsevidenceandroleofinflammasomesignalingreviewed |