The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyt...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/462152 |
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| author | Xiao-Kai Guo Yuan-Feng Liu Yu Zhou Xiu-Yuan Sun Xiao-Ping Qian Yu Zhang Jun Zhang |
| author_facet | Xiao-Kai Guo Yuan-Feng Liu Yu Zhou Xiu-Yuan Sun Xiao-Ping Qian Yu Zhang Jun Zhang |
| author_sort | Xiao-Kai Guo |
| collection | DOAJ |
| description | Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development. |
| format | Article |
| id | doaj-art-ea4f3f40b8264a8ebb1959e6cff5e31b |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ea4f3f40b8264a8ebb1959e6cff5e31b2025-08-20T03:26:34ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/462152462152The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and MigrationXiao-Kai Guo0Yuan-Feng Liu1Yu Zhou2Xiu-Yuan Sun3Xiao-Ping Qian4Yu Zhang5Jun Zhang6Department of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaDepartment of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaDepartment of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaDepartment of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaDepartment of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaDepartment of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaDepartment of Immunology, Key Laboratory of Medical Immunology (Ministry of Health), School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, ChinaNetrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development.http://dx.doi.org/10.1155/2013/462152 |
| spellingShingle | Xiao-Kai Guo Yuan-Feng Liu Yu Zhou Xiu-Yuan Sun Xiao-Ping Qian Yu Zhang Jun Zhang The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration Clinical and Developmental Immunology |
| title | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
| title_full | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
| title_fullStr | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
| title_full_unstemmed | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
| title_short | The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration |
| title_sort | expression of netrin 1 in the thymus and its effects on thymocyte adhesion and migration |
| url | http://dx.doi.org/10.1155/2013/462152 |
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