Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus
Transplacental ultrasound-guided intrauterine transfusion (IUT) acts as a lifesaving therapy to prevent fetal anemia or even to reverse fetal hydrops. IUTs are generally initiated after 22–24 weeks of gestation and repeated every 2–4-week period of gestation. Although Rh-Kell phenotype-matched, fres...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Asian Journal of Transfusion Science |
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| Online Access: | https://journals.lww.com/10.4103/ajts.ajts_155_23 |
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| author | Suhasini Sil Daljit Kaur Latika Chawla Dixa Kumari Madhulika Singh Vaidehi Prasanth Ashish Jain Gita Negi |
| author_facet | Suhasini Sil Daljit Kaur Latika Chawla Dixa Kumari Madhulika Singh Vaidehi Prasanth Ashish Jain Gita Negi |
| author_sort | Suhasini Sil |
| collection | DOAJ |
| description | Transplacental ultrasound-guided intrauterine transfusion (IUT) acts as a lifesaving therapy to prevent fetal anemia or even to reverse fetal hydrops. IUTs are generally initiated after 22–24 weeks of gestation and repeated every 2–4-week period of gestation. Although Rh-Kell phenotype-matched, fresh irradiated leukoreduced donor-packed red cells help to increase fetal hemoglobin level, this invasive procedure can increase fetal complications by fetomaternal hemorrhage. Women receiving IUTs are noted to be high allo-responders to red cell antigens, which can cause enhanced antibody titer or the formation of additional antibodies which might complicate future pregnancies. Hereby, we are reporting the case of a multiparous woman who underwent three sessions of IUTs between 24 weeks and 31+-week period of gestation and developed an additional anti-C antibody which was incidentally detected during compatibility testing at 34 weeks, along with raised anti-D immunoglobulin G titer of 1024 from initial titer of 128. |
| format | Article |
| id | doaj-art-ea481953eea746fe9e9bfe9fc513fc1d |
| institution | Kabale University |
| issn | 0973-6247 1998-3565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj-art-ea481953eea746fe9e9bfe9fc513fc1d2025-08-20T03:44:28ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652025-07-0119114114410.4103/ajts.ajts_155_23Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetusSuhasini SilDaljit KaurLatika ChawlaDixa KumariMadhulika SinghVaidehi PrasanthAshish JainGita NegiTransplacental ultrasound-guided intrauterine transfusion (IUT) acts as a lifesaving therapy to prevent fetal anemia or even to reverse fetal hydrops. IUTs are generally initiated after 22–24 weeks of gestation and repeated every 2–4-week period of gestation. Although Rh-Kell phenotype-matched, fresh irradiated leukoreduced donor-packed red cells help to increase fetal hemoglobin level, this invasive procedure can increase fetal complications by fetomaternal hemorrhage. Women receiving IUTs are noted to be high allo-responders to red cell antigens, which can cause enhanced antibody titer or the formation of additional antibodies which might complicate future pregnancies. Hereby, we are reporting the case of a multiparous woman who underwent three sessions of IUTs between 24 weeks and 31+-week period of gestation and developed an additional anti-C antibody which was incidentally detected during compatibility testing at 34 weeks, along with raised anti-D immunoglobulin G titer of 1024 from initial titer of 128.https://journals.lww.com/10.4103/ajts.ajts_155_23allo-immunizationanti-c antibodyanti-d antibodyhemolytic disease of fetus and newbornintrauterine transfusion |
| spellingShingle | Suhasini Sil Daljit Kaur Latika Chawla Dixa Kumari Madhulika Singh Vaidehi Prasanth Ashish Jain Gita Negi Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus Asian Journal of Transfusion Science allo-immunization anti-c antibody anti-d antibody hemolytic disease of fetus and newborn intrauterine transfusion |
| title | Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus |
| title_full | Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus |
| title_fullStr | Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus |
| title_full_unstemmed | Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus |
| title_short | Emergence of additional anti-C with amplification of anti-D titer post-Rh-Kell phenotype-matched intrauterine transfusions in severe hemolytic disease of fetus |
| title_sort | emergence of additional anti c with amplification of anti d titer post rh kell phenotype matched intrauterine transfusions in severe hemolytic disease of fetus |
| topic | allo-immunization anti-c antibody anti-d antibody hemolytic disease of fetus and newborn intrauterine transfusion |
| url | https://journals.lww.com/10.4103/ajts.ajts_155_23 |
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