Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats
Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, p...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Endocrine and Metabolic Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396125000214 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849701415181615104 |
|---|---|
| author | Sherif A. Abdelmottaleb Moussa Fatma A.A. Ibrahim Marawan Abd Elbaset Fatma A. Morsy Samir W. Aziz Noha A. Abd El-Latif Sherif M. Afifi Tuba Esatbeyoglu Sayed A. El Toumy Josline Y. Salib Samir A.E. Bashandy |
| author_facet | Sherif A. Abdelmottaleb Moussa Fatma A.A. Ibrahim Marawan Abd Elbaset Fatma A. Morsy Samir W. Aziz Noha A. Abd El-Latif Sherif M. Afifi Tuba Esatbeyoglu Sayed A. El Toumy Josline Y. Salib Samir A.E. Bashandy |
| author_sort | Sherif A. Abdelmottaleb Moussa |
| collection | DOAJ |
| description | Thyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications. |
| format | Article |
| id | doaj-art-ea45c683eaf04453b82555edaade9bba |
| institution | DOAJ |
| issn | 2666-3961 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj-art-ea45c683eaf04453b82555edaade9bba2025-08-20T03:17:57ZengElsevierEndocrine and Metabolic Science2666-39612025-06-011810023510.1016/j.endmts.2025.100235Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male ratsSherif A. Abdelmottaleb Moussa0Fatma A.A. Ibrahim1Marawan Abd Elbaset2Fatma A. Morsy3Samir W. Aziz4Noha A. Abd El-Latif5Sherif M. Afifi6Tuba Esatbeyoglu7Sayed A. El Toumy8Josline Y. Salib9Samir A.E. Bashandy10Department of Biochemistry, National Research Centre, P.SO. 12622, Cairo, Egypt; Corresponding authors.Department of Biochemistry, National Research Centre, P.SO. 12622, Cairo, EgyptDepartment of Pharmacology, National Research Centre, P.O. 12622, Cairo, EgyptPathology Department, National Research Centre, P.O. 12622, Cairo, EgyptDepartment of Biochemistry, National Research Centre, P.SO. 12622, Cairo, EgyptDepartment of Biochemistry, National Research Centre, P.SO. 12622, Cairo, EgyptDepartment for Life Quality Studies, Rimini Campus, University of Bologna, Corso d'Augusto 237, 47921 Rimini, ItalyDepartment of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany; Corresponding authors.Department of Tannins Chemistry, National Research Centre, P.O. 12622, Cairo, EgyptDepartment of Tannins Chemistry, National Research Centre, P.O. 12622, Cairo, EgyptDepartment of Pharmacology, National Research Centre, P.O. 12622, Cairo, EgyptThyme, belonging to the family Lamiaceae, stands out as a noteworthy herb with diverse applications. This study investigates the impact of Thymus vulgaris seed extract administration on hepatic oxidative burden, insulin sensitivity, and liver function in obese rats. The T. vulgaris-treated groups, particularly the high-dose (400 mg/kg) group, showed substantial reductions in waist size, body weight, and BMI compared to the obese group. While reducing inflammatory markers, T. vulgaris seed extract supplementation demonstrated significant improvements in lipid profiles, insulin resistance, liver function, and antioxidant status. Histopathological examination of hepatic tissues confirmed the curing effects of T. vulgaris seed extract, as shown by improvements in hepatic architecture and a reduction in the deleterious changes induced by obesity. LC-MS was used to identify 32 metabolites in the seed extract of T. vulgaris with methoxyflavonoids as the most prevalent class. In conclusion, T. vulgaris seed extract administration exhibited promising anti-obesity effects, influencing anthropometric measures, lipid profiles, insulin resistance, liver function, and inflammatory and hepatic oxidative stress markers in obese rats. The study culminated in the potential therapeutic role of T. vulgaris seed in managing obesity-related complications.http://www.sciencedirect.com/science/article/pii/S2666396125000214ObesityLiverThymeOxidative stressInsulin resistance |
| spellingShingle | Sherif A. Abdelmottaleb Moussa Fatma A.A. Ibrahim Marawan Abd Elbaset Fatma A. Morsy Samir W. Aziz Noha A. Abd El-Latif Sherif M. Afifi Tuba Esatbeyoglu Sayed A. El Toumy Josline Y. Salib Samir A.E. Bashandy Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats Endocrine and Metabolic Science Obesity Liver Thyme Oxidative stress Insulin resistance |
| title | Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats |
| title_full | Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats |
| title_fullStr | Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats |
| title_full_unstemmed | Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats |
| title_short | Thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats |
| title_sort | thymus vulgaris seed extract hampered hepatic oxidative burden and improved insulin sensitivity in obese male rats |
| topic | Obesity Liver Thyme Oxidative stress Insulin resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2666396125000214 |
| work_keys_str_mv | AT sherifaabdelmottalebmoussa thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT fatmaaaibrahim thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT marawanabdelbaset thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT fatmaamorsy thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT samirwaziz thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT nohaaabdellatif thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT sherifmafifi thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT tubaesatbeyoglu thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT sayedaeltoumy thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT joslineysalib thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats AT samiraebashandy thymusvulgarisseedextracthamperedhepaticoxidativeburdenandimprovedinsulinsensitivityinobesemalerats |