Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications
Influenza is an acute respiratory viral infection, known for its epidemics and pandemics, claiming millions of lives everywhere. Influenza A virus (Orthomyxoviridae family), whose genome consists of 8 RNA segments of negative polarity, is widespread due to its patterns of variability, which determin...
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| Language: | Russian |
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LLC "Publishing House OKI"
2024-06-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1128 |
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| author | M. N. Dunaeva |
| author_facet | M. N. Dunaeva |
| author_sort | M. N. Dunaeva |
| collection | DOAJ |
| description | Influenza is an acute respiratory viral infection, known for its epidemics and pandemics, claiming millions of lives everywhere. Influenza A virus (Orthomyxoviridae family), whose genome consists of 8 RNA segments of negative polarity, is widespread due to its patterns of variability, which determine the development of resistance, for example, to antiviral drugs. Reassortment mechanisms and point mutations in the influenza A virus genome can lead to a great variety of different variants of this pathogen. The considered life cycle of the influenza A virus with a detailed description of the molecular genetic features of its structures allows us to highlight the advantages and disadvantages of the etiotropic therapy used, affecting different stages of virus replication from the point of view of evidence-based medicine in aspects related to its resistance. |
| format | Article |
| id | doaj-art-ea4065bc73a246aebc23d090e04f4c8c |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-ea4065bc73a246aebc23d090e04f4c8c2025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902024-06-01693-4739410.37489/0235-2990-2024-69-3-4-73-941033Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic MedicationsM. N. Dunaeva0Scientific Research Institute of Epidemiology and Microbiology named after G. P. Somov of Federal Service for the Oversight of Consumer Protection and Welfare; Far Eastern Federal UniversityInfluenza is an acute respiratory viral infection, known for its epidemics and pandemics, claiming millions of lives everywhere. Influenza A virus (Orthomyxoviridae family), whose genome consists of 8 RNA segments of negative polarity, is widespread due to its patterns of variability, which determine the development of resistance, for example, to antiviral drugs. Reassortment mechanisms and point mutations in the influenza A virus genome can lead to a great variety of different variants of this pathogen. The considered life cycle of the influenza A virus with a detailed description of the molecular genetic features of its structures allows us to highlight the advantages and disadvantages of the etiotropic therapy used, affecting different stages of virus replication from the point of view of evidence-based medicine in aspects related to its resistance.https://www.antibiotics-chemotherapy.ru/jour/article/view/1128acute respiratory viral infectionsarviinfluenzamolecular geneticsmutationsresistanceantiviral drugsrational therapy |
| spellingShingle | M. N. Dunaeva Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications Антибиотики и Химиотерапия acute respiratory viral infections arvi influenza molecular genetics mutations resistance antiviral drugs rational therapy |
| title | Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications |
| title_full | Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications |
| title_fullStr | Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications |
| title_full_unstemmed | Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications |
| title_short | Molecular Genetic Mechanisms of Influenza A Virus Replication and Mechanisms of Action of Etiotropic Medications |
| title_sort | molecular genetic mechanisms of influenza a virus replication and mechanisms of action of etiotropic medications |
| topic | acute respiratory viral infections arvi influenza molecular genetics mutations resistance antiviral drugs rational therapy |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1128 |
| work_keys_str_mv | AT mndunaeva moleculargeneticmechanismsofinfluenzaavirusreplicationandmechanismsofactionofetiotropicmedications |