Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction
Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symp...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2013/173184 |
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| author | Andrea Ciavattini Jacopo Di Giuseppe Piergiorgio Stortoni Nina Montik Stefano R. Giannubilo Pietro Litta Md. Soriful Islam Andrea L. Tranquilli Fernando M. Reis Pasquapina Ciarmela |
| author_facet | Andrea Ciavattini Jacopo Di Giuseppe Piergiorgio Stortoni Nina Montik Stefano R. Giannubilo Pietro Litta Md. Soriful Islam Andrea L. Tranquilli Fernando M. Reis Pasquapina Ciarmela |
| author_sort | Andrea Ciavattini |
| collection | DOAJ |
| description | Uterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium. |
| format | Article |
| id | doaj-art-ea3f3d7368e54eb2adfccc793116ce9b |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-ea3f3d7368e54eb2adfccc793116ce9b2025-02-03T01:02:34ZengWileyObstetrics and Gynecology International1687-95891687-95972013-01-01201310.1155/2013/173184173184Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial JunctionAndrea Ciavattini0Jacopo Di Giuseppe1Piergiorgio Stortoni2Nina Montik3Stefano R. Giannubilo4Pietro Litta5Md. Soriful Islam6Andrea L. Tranquilli7Fernando M. Reis8Pasquapina Ciarmela9Woman's Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, ItalyWoman's Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, ItalyWoman's Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, ItalyWoman's Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, ItalyWoman's Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, ItalyDepartment of Gynaecological Sciences and Human Reproduction, University of Padova, Via Giustiniani 3, 35128 Padova, ItalyDepartment of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60126 Ancona, ItalyWoman's Health Sciences Department, Faculty of Medicine, Polytechnic University of Marche, Via Corridoni 11, 60123 Ancona, ItalyDepartment of Obstetrics and Gynecology, Federal University of Minas Gerais and National Institute of Hormones and Women’s Health, 30130-100 Belo Horizonte, MG, BrazilDepartment of Experimental and Clinical Medicine, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60126 Ancona, ItalyUterine leiomyomas (fibroids or myomas) are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium.http://dx.doi.org/10.1155/2013/173184 |
| spellingShingle | Andrea Ciavattini Jacopo Di Giuseppe Piergiorgio Stortoni Nina Montik Stefano R. Giannubilo Pietro Litta Md. Soriful Islam Andrea L. Tranquilli Fernando M. Reis Pasquapina Ciarmela Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction Obstetrics and Gynecology International |
| title | Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction |
| title_full | Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction |
| title_fullStr | Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction |
| title_full_unstemmed | Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction |
| title_short | Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction |
| title_sort | uterine fibroids pathogenesis and interactions with endometrium and endomyometrial junction |
| url | http://dx.doi.org/10.1155/2013/173184 |
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