Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study
Abstract Background and objective Bitter gourd, also known as bitter melon, contains a variety of phytochemicals, including alkaloids, saponins, and flavonoids. This study investigates the effect of bitter gourd juice on glucose levels in streptozotocin-induced diabetic rats, providing nutritional c...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Discover Food |
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| Online Access: | https://doi.org/10.1007/s44187-025-00564-7 |
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| author | Qali Ahmed Nageye Walid Abdulkadir Osman Hassan Muse Ahmed Idil Abdikarin Adam Saeed Mohamed Saeed |
| author_facet | Qali Ahmed Nageye Walid Abdulkadir Osman Hassan Muse Ahmed Idil Abdikarin Adam Saeed Mohamed Saeed |
| author_sort | Qali Ahmed Nageye |
| collection | DOAJ |
| description | Abstract Background and objective Bitter gourd, also known as bitter melon, contains a variety of phytochemicals, including alkaloids, saponins, and flavonoids. This study investigates the effect of bitter gourd juice on glucose levels in streptozotocin-induced diabetic rats, providing nutritional composition, phytochemical profiling, and anti-diabetic efficacy. Methods and materials Trials were structured as open-label, double-arm studies lasting 60 days. Clinical assessments were performed weekly, and longitudinal data were collected throughout the study. A total of 15 rats were divided into three groups of five. One group served as the control (T1), whereas the other two groups (T2 and T3) were fed a functional diet containing different levels of bitter gourd (30% and 50%, respectively). Results The administration of 30% and 50% bitter gourd juice significantly reduced glucose levels in diabetic rats, with the 50% group exhibiting a 50% decrease. After seven weeks, glucose levels were 197.4 ± 14.32 mg/dL for the control group, 107 ± 4.69 mg/dL for the 30% group, and 85.6 ± 4.82 mg/dL for the 50% group (p < 0.001). HbA1c levels also decreased, measuring 6.7 ± 0.16 in the control, 5.46 ± 0.23 in the 30% group, and 4.6 ± 0.22 in the 50% group, highlighting the efficacy of bitter gourd treatment in lowering glycemic levels. Conclusion The findings suggest that bitter gourd may be an effective treatment for diabetes due to its high levels of beneficial phytochemicals. |
| format | Article |
| id | doaj-art-ea39faaada40484f8a3f3a2b03e2926f |
| institution | Kabale University |
| issn | 2731-4286 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Food |
| spelling | doaj-art-ea39faaada40484f8a3f3a2b03e2926f2025-08-20T03:43:02ZengSpringerDiscover Food2731-42862025-08-015111010.1007/s44187-025-00564-7Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental studyQali Ahmed Nageye0Walid Abdulkadir Osman1Hassan Muse Ahmed2Idil Abdikarin Adam3Saeed Mohamed Saeed4Faculty of Health Sciences, Mogadishu UniversityFaculty of Health Sciences, Mogadishu UniversityFaculty of Health Sciences, Mogadishu UniversityFaculty of Health Sciences, Mogadishu UniversityFaculty of Health Sciences, Mogadishu UniversityAbstract Background and objective Bitter gourd, also known as bitter melon, contains a variety of phytochemicals, including alkaloids, saponins, and flavonoids. This study investigates the effect of bitter gourd juice on glucose levels in streptozotocin-induced diabetic rats, providing nutritional composition, phytochemical profiling, and anti-diabetic efficacy. Methods and materials Trials were structured as open-label, double-arm studies lasting 60 days. Clinical assessments were performed weekly, and longitudinal data were collected throughout the study. A total of 15 rats were divided into three groups of five. One group served as the control (T1), whereas the other two groups (T2 and T3) were fed a functional diet containing different levels of bitter gourd (30% and 50%, respectively). Results The administration of 30% and 50% bitter gourd juice significantly reduced glucose levels in diabetic rats, with the 50% group exhibiting a 50% decrease. After seven weeks, glucose levels were 197.4 ± 14.32 mg/dL for the control group, 107 ± 4.69 mg/dL for the 30% group, and 85.6 ± 4.82 mg/dL for the 50% group (p < 0.001). HbA1c levels also decreased, measuring 6.7 ± 0.16 in the control, 5.46 ± 0.23 in the 30% group, and 4.6 ± 0.22 in the 50% group, highlighting the efficacy of bitter gourd treatment in lowering glycemic levels. Conclusion The findings suggest that bitter gourd may be an effective treatment for diabetes due to its high levels of beneficial phytochemicals.https://doi.org/10.1007/s44187-025-00564-7Momordica charantiaBlood sugar regulationComplementary medicineAnimal models |
| spellingShingle | Qali Ahmed Nageye Walid Abdulkadir Osman Hassan Muse Ahmed Idil Abdikarin Adam Saeed Mohamed Saeed Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study Discover Food Momordica charantia Blood sugar regulation Complementary medicine Animal models |
| title | Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study |
| title_full | Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study |
| title_fullStr | Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study |
| title_full_unstemmed | Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study |
| title_short | Effect of bitter gourd juice on glucose level in streptozotocin-induced diabetic rats: an experimental study |
| title_sort | effect of bitter gourd juice on glucose level in streptozotocin induced diabetic rats an experimental study |
| topic | Momordica charantia Blood sugar regulation Complementary medicine Animal models |
| url | https://doi.org/10.1007/s44187-025-00564-7 |
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