Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities
Background and objectiveCarotid plaque Crouse score and serum homocysteine (Hcy) are closely associated with white matter hyperintensities (WMH). In recent years, it had been found that the pathological mechanism of periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH) was different. In this...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1533108/full |
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| author | Yue Liu Xintao Tian Xinrui Cheng Chunyan Jia Cuiping Li Shaonan Yang |
| author_facet | Yue Liu Xintao Tian Xinrui Cheng Chunyan Jia Cuiping Li Shaonan Yang |
| author_sort | Yue Liu |
| collection | DOAJ |
| description | Background and objectiveCarotid plaque Crouse score and serum homocysteine (Hcy) are closely associated with white matter hyperintensities (WMH). In recent years, it had been found that the pathological mechanism of periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH) was different. In this study, we aimed to further determine the respective effects of Carotid plaque Crouse score and serum Hcy on the location of WMH.MethodsWe recruited 284 patients with lacunar infarction admitted to the Affiliated Hospital of Qingdao University and conducted a retrospective cohort study. The level of serum Hcy was determined by ELISA. Carotid plaque Crouse score was evaluated by cervical vascular ultrasound. The severity of PVWMH and DSWMH was graded using a manual rating scale. Logistic regression analysis was performed to explore the relationship between Crouse score, serum Hcy and PVWMH and/or DSWMH. The critical point which Crouse score and serum Hcy played a role was determined by Quartile method.ResultsAfter adjusting for confounding variables, Logistic regression showed that PVWMH was associated with age, hypertension, Hcy and Crouse score; DSWMH was associated with age, hypertension, and Crouse score but not with Hcy. Quartile analysis indicated that Crouse score > 0.39 was associated with the occurrence of PVWMH and DSWMH, while Hcy > 12.48 was only associated with the occurrence of PVWMH.ConclusionCrouse score is associated with both PVWMH and DSWMH. High levels of Hcy is associated with the occurrence of PVWMH, but not DSWMH. |
| format | Article |
| id | doaj-art-ea38f93eeae94033bb4c2c4c7cc7da19 |
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| issn | 1664-2295 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-ea38f93eeae94033bb4c2c4c7cc7da192025-08-20T01:55:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-04-011610.3389/fneur.2025.15331081533108Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensitiesYue Liu0Xintao Tian1Xinrui Cheng2Chunyan Jia3Cuiping Li4Shaonan Yang5Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Urology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaBackground and objectiveCarotid plaque Crouse score and serum homocysteine (Hcy) are closely associated with white matter hyperintensities (WMH). In recent years, it had been found that the pathological mechanism of periventricular WMH (PVWMH) and deep subcortical WMH (DSWMH) was different. In this study, we aimed to further determine the respective effects of Carotid plaque Crouse score and serum Hcy on the location of WMH.MethodsWe recruited 284 patients with lacunar infarction admitted to the Affiliated Hospital of Qingdao University and conducted a retrospective cohort study. The level of serum Hcy was determined by ELISA. Carotid plaque Crouse score was evaluated by cervical vascular ultrasound. The severity of PVWMH and DSWMH was graded using a manual rating scale. Logistic regression analysis was performed to explore the relationship between Crouse score, serum Hcy and PVWMH and/or DSWMH. The critical point which Crouse score and serum Hcy played a role was determined by Quartile method.ResultsAfter adjusting for confounding variables, Logistic regression showed that PVWMH was associated with age, hypertension, Hcy and Crouse score; DSWMH was associated with age, hypertension, and Crouse score but not with Hcy. Quartile analysis indicated that Crouse score > 0.39 was associated with the occurrence of PVWMH and DSWMH, while Hcy > 12.48 was only associated with the occurrence of PVWMH.ConclusionCrouse score is associated with both PVWMH and DSWMH. High levels of Hcy is associated with the occurrence of PVWMH, but not DSWMH.https://www.frontiersin.org/articles/10.3389/fneur.2025.1533108/fullCrouse scoreHcyCSVDWMHPVWMHDSWMH |
| spellingShingle | Yue Liu Xintao Tian Xinrui Cheng Chunyan Jia Cuiping Li Shaonan Yang Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities Frontiers in Neurology Crouse score Hcy CSVD WMH PVWMH DSWMH |
| title | Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities |
| title_full | Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities |
| title_fullStr | Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities |
| title_full_unstemmed | Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities |
| title_short | Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities |
| title_sort | effects of carotid plaque crouse score and serum hcy on the location of white matter hyperintensities |
| topic | Crouse score Hcy CSVD WMH PVWMH DSWMH |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1533108/full |
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