Identifying Inhibitor-SARS-CoV2-3CL<sup>pro</sup> Binding Mechanism Through Molecular Docking, GaMD Simulations, Correlation Network Analysis and MM-GBSA Calculations

The main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), known as 3CL<sup>pro</sup>, is crucial in the virus’s life cycle and plays a pivotal role in COVID-19. Understanding how small molecules inhibit 3CL<sup>pro</sup>’s activity is vital for de...

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Bibliographic Details
Main Authors: Jianzhong Chen, Jian Wang, Wanchun Yang, Lu Zhao, Xiaoyan Xu
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
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Online Access:https://www.mdpi.com/1420-3049/30/4/805
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