Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios
Background: The reason for increased serum creatinine levels in preterm infants often remains unclear. We aimed to determine whether postnatal serum creatinine in preterm infants correlates with intake of amniotic fluid, represented by the amount of amniotic fluid after preterm premature rupture of...
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Elsevier
2020-08-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957220300498 |
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| author | Nora Bruns Ann-Christin Stähling Sandra Greve Christel Weiss Angela Köninger Ursula Felderhoff-Müser Hanna Müller |
| author_facet | Nora Bruns Ann-Christin Stähling Sandra Greve Christel Weiss Angela Köninger Ursula Felderhoff-Müser Hanna Müller |
| author_sort | Nora Bruns |
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| description | Background: The reason for increased serum creatinine levels in preterm infants often remains unclear. We aimed to determine whether postnatal serum creatinine in preterm infants correlates with intake of amniotic fluid, represented by the amount of amniotic fluid after preterm premature rupture of membranes (PPROM). Methods: 74 preterm infants with PPROM > 48 h duration were retrospectively studied. Postnatal creatinine concentration was determined at day 2–5, 10–17 and 26–33 of life and compared between infants with normal intrauterine amniotic volumes, oligohydramnios and anhydramnios. Results: Mean gestational age of included patients was 29.7 weeks (range: 24.0–36.1 weeks) and mean birth weight was 1452 g (range: 560–2940 g). Serum creatinine concentration was similar at day 2–5 and day 10–17 of life between the three groups. We observed a significant decrease in creatinine concentration from day 2–5 to day 26–33 in infants with normal amniotic fluid volume and oligohydramnios (p = 0.0001 and p = 0.0071, respectively), but not in anhydramnios. On day 26–33 of life, infants with anhydramnios showed significantly higher creatinine levels compared to infants with normal amniotic fluid volume and oligohydramnios (p = 0.0211). Conclusion: Postnatal serum creatinine of preterm infants at day 26–33 of life is elevated in infants with PPROM-induced anhydramnios, but not in oligohydramnios. |
| format | Article |
| id | doaj-art-ea30c8d3dc4440b88ed127212f21933f |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
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| series | Pediatrics and Neonatology |
| spelling | doaj-art-ea30c8d3dc4440b88ed127212f21933f2025-08-20T02:55:14ZengElsevierPediatrics and Neonatology1875-95722020-08-0161441441910.1016/j.pedneo.2020.03.010Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramniosNora Bruns0Ann-Christin Stähling1Sandra Greve2Christel Weiss3Angela Köninger4Ursula Felderhoff-Müser5Hanna Müller6Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, GermanyDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, GermanyDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, GermanyDepartment for Medical Statistics and Biomathematics, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, GermanyDepartment of Gynecology and Obstetrics, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, GermanyDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, GermanyDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany; Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University Hospital Erlangen, University of Erlangen-Nürnberg, Loschgestr. 15, 91054 Erlangen, Germany; Corresponding author. Division of Neonatology and Pediatric Intensive Care, Department of Pediatrics, University Hospital Erlangen, University of Erlangen-Nürnberg, Loschgestr. 15, 91054 Erlangen, Germany. Fax: +49 – 9131- 8535867.Background: The reason for increased serum creatinine levels in preterm infants often remains unclear. We aimed to determine whether postnatal serum creatinine in preterm infants correlates with intake of amniotic fluid, represented by the amount of amniotic fluid after preterm premature rupture of membranes (PPROM). Methods: 74 preterm infants with PPROM > 48 h duration were retrospectively studied. Postnatal creatinine concentration was determined at day 2–5, 10–17 and 26–33 of life and compared between infants with normal intrauterine amniotic volumes, oligohydramnios and anhydramnios. Results: Mean gestational age of included patients was 29.7 weeks (range: 24.0–36.1 weeks) and mean birth weight was 1452 g (range: 560–2940 g). Serum creatinine concentration was similar at day 2–5 and day 10–17 of life between the three groups. We observed a significant decrease in creatinine concentration from day 2–5 to day 26–33 in infants with normal amniotic fluid volume and oligohydramnios (p = 0.0001 and p = 0.0071, respectively), but not in anhydramnios. On day 26–33 of life, infants with anhydramnios showed significantly higher creatinine levels compared to infants with normal amniotic fluid volume and oligohydramnios (p = 0.0211). Conclusion: Postnatal serum creatinine of preterm infants at day 26–33 of life is elevated in infants with PPROM-induced anhydramnios, but not in oligohydramnios.http://www.sciencedirect.com/science/article/pii/S1875957220300498amniotic fluidanhydramniospreterm infantpreterm premature rupture of membranesserum creatinine |
| spellingShingle | Nora Bruns Ann-Christin Stähling Sandra Greve Christel Weiss Angela Köninger Ursula Felderhoff-Müser Hanna Müller Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios Pediatrics and Neonatology amniotic fluid anhydramnios preterm infant preterm premature rupture of membranes serum creatinine |
| title | Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios |
| title_full | Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios |
| title_fullStr | Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios |
| title_full_unstemmed | Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios |
| title_short | Postnatal serum creatinine is elevated in preterm infants with PPROM-induced anhydramnios |
| title_sort | postnatal serum creatinine is elevated in preterm infants with pprom induced anhydramnios |
| topic | amniotic fluid anhydramnios preterm infant preterm premature rupture of membranes serum creatinine |
| url | http://www.sciencedirect.com/science/article/pii/S1875957220300498 |
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