β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese
Objectives. Several serum biomarkers have been reported to increase in periodontitis patients as possible mediators linking periodontal inflammation to systemic diseases. However, the relationship between periodontitis and urine biomarkers is still unclear. The aim of this cross-sectional study was...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2019/1394678 |
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| author | Mayuka Nakajima Michihiro Hosojima Koichi Tabeta Sayuri Miyauchi Miki Yamada-Hara Naoki Takahashi Haruna Miyazawa Yumi Matsuda-Matsukawa Keisuke Sato Noriko Sugita Yasutaka Komatsu Tomomi Ishikawa Kazuhiro Akiishi Kazuhisa Yamazaki Kiminori Kato Akihiko Saito Hiromasa Yoshie |
| author_facet | Mayuka Nakajima Michihiro Hosojima Koichi Tabeta Sayuri Miyauchi Miki Yamada-Hara Naoki Takahashi Haruna Miyazawa Yumi Matsuda-Matsukawa Keisuke Sato Noriko Sugita Yasutaka Komatsu Tomomi Ishikawa Kazuhiro Akiishi Kazuhisa Yamazaki Kiminori Kato Akihiko Saito Hiromasa Yoshie |
| author_sort | Mayuka Nakajima |
| collection | DOAJ |
| description | Objectives. Several serum biomarkers have been reported to increase in periodontitis patients as possible mediators linking periodontal inflammation to systemic diseases. However, the relationship between periodontitis and urine biomarkers is still unclear. The aim of this cross-sectional study was to investigate potential urine biomarkers of periodontitis in a Japanese population. Materials and Methods. This study included 108 male subjects, and microbiological and clinical parameters were evaluated as a periodontitis marker. The correlation between nine urine biomarkers (typically used to diagnose kidney disease) and periodontal parameters was analyzed. Based on the findings, β2-microglobulin (β2-MG) and neutrophil gelatinase-associated lipocalin (NGAL) were selected for comparison and multivariate regression analysis, and the Kruskal–Wallis test followed by Bonferroni correction was used to identify differences in their concentrations between the three periodontitis groups (severe, moderate, and no/mild periodontitis). Results. β2-MG and NGAL exhibited a significant correlation with clinical parameters of periodontitis. The prevalence of clinical parameters such as bleeding on probing and number of sites with probing depth (PD) ≥ 6 mm were greater in the β2-MG high group (≥300 μg/g creatinine) than in the normal group (P=0.017 and 0.019, respectively). Multivariate regression analysis indicated that the number of sites with PD ≥ 6 mm was independently associated with urine β2-MG. Moreover, the number of sites with the clinical attachment level (CAL) ≥ 6 mm was greater in the NGAL high group (highest quartile) (P=0.041). Multivariate regression analysis showed that the number of sites with CAL ≥ 6 mm was associated independently with urine NGAL. Finally, β2-MG was significantly higher in the severe periodontitis subjects compared to the no/mild periodontitis subjects. Conclusion. The significant association between urine β2-MG or NGAL and periodontitis was revealed. These biomarkers can potentially be used to screen for or diagnose periodontitis. This trial is registered with the UMIN Clinical Trials Registry UMIN000013485. |
| format | Article |
| id | doaj-art-ea2c7f80f7c8495499b23e7c050771ab |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | International Journal of Dentistry |
| spelling | doaj-art-ea2c7f80f7c8495499b23e7c050771ab2025-02-03T01:27:33ZengWileyInternational Journal of Dentistry1687-87281687-87362019-01-01201910.1155/2019/13946781394678β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in JapaneseMayuka Nakajima0Michihiro Hosojima1Koichi Tabeta2Sayuri Miyauchi3Miki Yamada-Hara4Naoki Takahashi5Haruna Miyazawa6Yumi Matsuda-Matsukawa7Keisuke Sato8Noriko Sugita9Yasutaka Komatsu10Tomomi Ishikawa11Kazuhiro Akiishi12Kazuhisa Yamazaki13Kiminori Kato14Akihiko Saito15Hiromasa Yoshie16Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDepartment of Clinical Nutrition Science, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, JapanReagent R&D Department, Denka Seiken Co. Ltd., 1359-1, Kagamida, Kigoshi, Gosen-shi, Niigata 959-1695, JapanResearch Unit for Oral-Systemic Connection, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanDepartment of Laboratory Medicine and Clinical Epidemiology for Prevention of Noncommunicable Diseases, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, JapanDepartment of Applied Molecular Medicine, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata 951-8510, JapanDivision of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Science, 2-5274 Gakko-cho, Chuo-ku, Niigata 951-8514, JapanObjectives. Several serum biomarkers have been reported to increase in periodontitis patients as possible mediators linking periodontal inflammation to systemic diseases. However, the relationship between periodontitis and urine biomarkers is still unclear. The aim of this cross-sectional study was to investigate potential urine biomarkers of periodontitis in a Japanese population. Materials and Methods. This study included 108 male subjects, and microbiological and clinical parameters were evaluated as a periodontitis marker. The correlation between nine urine biomarkers (typically used to diagnose kidney disease) and periodontal parameters was analyzed. Based on the findings, β2-microglobulin (β2-MG) and neutrophil gelatinase-associated lipocalin (NGAL) were selected for comparison and multivariate regression analysis, and the Kruskal–Wallis test followed by Bonferroni correction was used to identify differences in their concentrations between the three periodontitis groups (severe, moderate, and no/mild periodontitis). Results. β2-MG and NGAL exhibited a significant correlation with clinical parameters of periodontitis. The prevalence of clinical parameters such as bleeding on probing and number of sites with probing depth (PD) ≥ 6 mm were greater in the β2-MG high group (≥300 μg/g creatinine) than in the normal group (P=0.017 and 0.019, respectively). Multivariate regression analysis indicated that the number of sites with PD ≥ 6 mm was independently associated with urine β2-MG. Moreover, the number of sites with the clinical attachment level (CAL) ≥ 6 mm was greater in the NGAL high group (highest quartile) (P=0.041). Multivariate regression analysis showed that the number of sites with CAL ≥ 6 mm was associated independently with urine NGAL. Finally, β2-MG was significantly higher in the severe periodontitis subjects compared to the no/mild periodontitis subjects. Conclusion. The significant association between urine β2-MG or NGAL and periodontitis was revealed. These biomarkers can potentially be used to screen for or diagnose periodontitis. This trial is registered with the UMIN Clinical Trials Registry UMIN000013485.http://dx.doi.org/10.1155/2019/1394678 |
| spellingShingle | Mayuka Nakajima Michihiro Hosojima Koichi Tabeta Sayuri Miyauchi Miki Yamada-Hara Naoki Takahashi Haruna Miyazawa Yumi Matsuda-Matsukawa Keisuke Sato Noriko Sugita Yasutaka Komatsu Tomomi Ishikawa Kazuhiro Akiishi Kazuhisa Yamazaki Kiminori Kato Akihiko Saito Hiromasa Yoshie β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese International Journal of Dentistry |
| title | β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese |
| title_full | β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese |
| title_fullStr | β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese |
| title_full_unstemmed | β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese |
| title_short | β2-Microglobulin and Neutrophil Gelatinase-Associated Lipocalin, Potential Novel Urine Biomarkers in Periodontitis: A Cross-Sectional Study in Japanese |
| title_sort | β2 microglobulin and neutrophil gelatinase associated lipocalin potential novel urine biomarkers in periodontitis a cross sectional study in japanese |
| url | http://dx.doi.org/10.1155/2019/1394678 |
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