Neutrophils: An Important Player in Systemic Lupus Erythematosus
The immune system contains several different cells that act as the first line of defence, reacting to a broad range of intruders as quickly as possible; an example of such cells is neutrophils. There has been increased focus on neutrophils due to the key role they potentially play in the pathogenesi...
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JCDR Research and Publications Private Limited
2025-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/21039/79481_CE[Ra1]_F(IS)_QC(AN_SS)_PF1(VD_SS)_PFA(IS)_PB(VD_IS)_PN(IS).pdf |
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| author | Nuha A Alkhattabi |
| author_facet | Nuha A Alkhattabi |
| author_sort | Nuha A Alkhattabi |
| collection | DOAJ |
| description | The immune system contains several different cells that act as the first line of defence, reacting to a broad range of intruders as quickly as possible; an example of such cells is neutrophils. There has been increased focus on neutrophils due to the key role they potentially play in the pathogenesis of various diseases caused by the overactivation or malfunctioning of these cells. Investigations have been conducted to explore the role of neutrophils in the pathogenesis of Systemic Lupus Erythematosus (SLE). The SLE is an autoimmune disorder in which one or multiple organs become inflamed or damaged, resulting in the release of autoantigens and subsequently activating B cells that produce autoantibodies. The severity of the disease, as well as the specific organs affected, can influence how it manifests in the individual patient, and it has the potential to be fatal. Disease development can be influenced by a combination of genetic and environmental factors. The process of diagnosing SLE is based on clinical signs and symptoms that evolve, thus creating diagnostic challenges and impacting the ability to anticipate how a patient will respond to treatment due to the heterogeneous nature of the disorder. Neutrophils play a key role in the development of SLE as they serve as a source of nuclear autoantigens, due to reduced phagocytosis and increased production of Neutrophil Extracellular Traps (NETs). The present review aimed to analyse the role of neutrophils, particularly in the context of SLE development. Additionally, it will discuss the potential for these cells to be involved in the diagnosis and treatment of SLE. |
| format | Article |
| id | doaj-art-ea2b948a1d544fd5a704bf6212d6c77a |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-ea2b948a1d544fd5a704bf6212d6c77a2025-08-20T03:47:52ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-05-01195BE01BE0510.7860/JCDR/2025/79481.21039Neutrophils: An Important Player in Systemic Lupus ErythematosusNuha A Alkhattabi0Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Western Region, Saudi Arabia.The immune system contains several different cells that act as the first line of defence, reacting to a broad range of intruders as quickly as possible; an example of such cells is neutrophils. There has been increased focus on neutrophils due to the key role they potentially play in the pathogenesis of various diseases caused by the overactivation or malfunctioning of these cells. Investigations have been conducted to explore the role of neutrophils in the pathogenesis of Systemic Lupus Erythematosus (SLE). The SLE is an autoimmune disorder in which one or multiple organs become inflamed or damaged, resulting in the release of autoantigens and subsequently activating B cells that produce autoantibodies. The severity of the disease, as well as the specific organs affected, can influence how it manifests in the individual patient, and it has the potential to be fatal. Disease development can be influenced by a combination of genetic and environmental factors. The process of diagnosing SLE is based on clinical signs and symptoms that evolve, thus creating diagnostic challenges and impacting the ability to anticipate how a patient will respond to treatment due to the heterogeneous nature of the disorder. Neutrophils play a key role in the development of SLE as they serve as a source of nuclear autoantigens, due to reduced phagocytosis and increased production of Neutrophil Extracellular Traps (NETs). The present review aimed to analyse the role of neutrophils, particularly in the context of SLE development. Additionally, it will discuss the potential for these cells to be involved in the diagnosis and treatment of SLE.https://jcdr.net/articles/PDF/21039/79481_CE[Ra1]_F(IS)_QC(AN_SS)_PF1(VD_SS)_PFA(IS)_PB(VD_IS)_PN(IS).pdfautoantigensautoimmunityenvironmental factorsgeneticsneutrophil extracellular traps |
| spellingShingle | Nuha A Alkhattabi Neutrophils: An Important Player in Systemic Lupus Erythematosus Journal of Clinical and Diagnostic Research autoantigens autoimmunity environmental factors genetics neutrophil extracellular traps |
| title | Neutrophils: An Important Player in Systemic Lupus Erythematosus |
| title_full | Neutrophils: An Important Player in Systemic Lupus Erythematosus |
| title_fullStr | Neutrophils: An Important Player in Systemic Lupus Erythematosus |
| title_full_unstemmed | Neutrophils: An Important Player in Systemic Lupus Erythematosus |
| title_short | Neutrophils: An Important Player in Systemic Lupus Erythematosus |
| title_sort | neutrophils an important player in systemic lupus erythematosus |
| topic | autoantigens autoimmunity environmental factors genetics neutrophil extracellular traps |
| url | https://jcdr.net/articles/PDF/21039/79481_CE[Ra1]_F(IS)_QC(AN_SS)_PF1(VD_SS)_PFA(IS)_PB(VD_IS)_PN(IS).pdf |
| work_keys_str_mv | AT nuhaaalkhattabi neutrophilsanimportantplayerinsystemiclupuserythematosus |