Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study
BackgroundThe n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.ObjectiveThis study aims to investigate age-rel...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-10-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1437587/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850284330640736256 |
|---|---|
| author | Shizhe Zhu Qinglei Wang Chaojie Kan Ayan Geng Youxin Sui Ren Zhuang Yi Zhu Tong Wang Lan Zhu Chuan Guo |
| author_facet | Shizhe Zhu Qinglei Wang Chaojie Kan Ayan Geng Youxin Sui Ren Zhuang Yi Zhu Tong Wang Lan Zhu Chuan Guo |
| author_sort | Shizhe Zhu |
| collection | DOAJ |
| description | BackgroundThe n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.ObjectiveThis study aims to investigate age-related differences in brain activation during the n-back task using fNIRS.MethodsfNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups.ResultsSignificant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group’s performance plateaued at the 2-back level, along with a decline in prefrontal activation.ConclusionThese findings may suggest potential markers for cognitive decline, providing a new target for future screening. |
| format | Article |
| id | doaj-art-ea258108d29b40a8a0506fdcfe5513fa |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-ea258108d29b40a8a0506fdcfe5513fa2025-08-20T01:47:36ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-10-011610.3389/fnagi.2024.14375871437587Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy studyShizhe Zhu0Qinglei Wang1Chaojie Kan2Ayan Geng3Youxin Sui4Ren Zhuang5Yi Zhu6Tong Wang7Lan Zhu8Chuan Guo9Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, Changzhou Dean Hospital, Changzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, ChinaDepartment of Rehabilitation Medicine, Changzhou Dean Hospital, Changzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaBackgroundThe n-back task is a widely used paradigm to assess working memory and is commonly applied in research on age-related cognitive decline. However, studies utilizing functional near-infrared spectroscopy (fNIRS) to explore this area are limited.ObjectiveThis study aims to investigate age-related differences in brain activation during the n-back task using fNIRS.MethodsfNIRS data were collected from 18 elderly and 19 young participants while performing different n-back tasks. Brain activation patterns and peripheral performance were compared between the two groups.ResultsSignificant differences in brain activation patterns were observed between elderly and young participants. Under the 3-back condition, the older group exhibited reduced activation in brain regions adjacent to prefrontal cognitive areas compared to the younger group. Additionally, the older group’s performance plateaued at the 2-back level, along with a decline in prefrontal activation.ConclusionThese findings may suggest potential markers for cognitive decline, providing a new target for future screening.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1437587/fullfNIRSagingn-backcerebral activationworking memory |
| spellingShingle | Shizhe Zhu Qinglei Wang Chaojie Kan Ayan Geng Youxin Sui Ren Zhuang Yi Zhu Tong Wang Lan Zhu Chuan Guo Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study Frontiers in Aging Neuroscience fNIRS aging n-back cerebral activation working memory |
| title | Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study |
| title_full | Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study |
| title_fullStr | Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study |
| title_full_unstemmed | Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study |
| title_short | Age-related cerebral changes during different n-back tasks: a functional near-infrared spectroscopy study |
| title_sort | age related cerebral changes during different n back tasks a functional near infrared spectroscopy study |
| topic | fNIRS aging n-back cerebral activation working memory |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1437587/full |
| work_keys_str_mv | AT shizhezhu agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT qingleiwang agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT chaojiekan agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT ayangeng agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT youxinsui agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT renzhuang agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT yizhu agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT tongwang agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT lanzhu agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy AT chuanguo agerelatedcerebralchangesduringdifferentnbacktasksafunctionalnearinfraredspectroscopystudy |