EMCV VP2 degrades IFI16 through Caspase-dependent apoptosis to evade IFI16-STING pathway

EMCV VP2 degrades IFI16 through Caspase-dependent apoptosis to evade IFI16-STING pathway

Abstract Interferon (IFN)-γ inducible protein 16 (IFI16), a key DNA sensor, triggers downstream STING-dependent type I interferon (IFN-I) production and antiviral immunity. However, how the IFI16-STING signaling pathway is regulated by EMCV infection is still not well elucidated. In this study, we i...

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Bibliographic Details
Main Authors: Ruofei Feng, Dianyu Li, Zhenfang Yan, Xiangrong Li, Jingying Xie
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Virology Journal
Subjects:
EMCV
IFI16
Viral protein VP2
Caspase-dependent apoptosis
Online Access:https://doi.org/10.1186/s12985-024-02568-8
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