Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases
Macrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body. It is well known that undif...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/8821610 |
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| author | Yuan Peng Mengxian Zhou Hong Yang Ruyi Qu Yan Qiu Jiawen Hao Hongsheng Bi Dadong Guo |
| author_facet | Yuan Peng Mengxian Zhou Hong Yang Ruyi Qu Yan Qiu Jiawen Hao Hongsheng Bi Dadong Guo |
| author_sort | Yuan Peng |
| collection | DOAJ |
| description | Macrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body. It is well known that undifferentiated macrophages can polarize into classically activated macrophages (M1 macrophages) and alternatively activated macrophages (M2 macrophages) under different microenvironmental conditions. The directions of macrophage polarization can be regulated by a series of factors, including interferon, lipopolysaccharide, interleukin, and noncoding RNAs. To elucidate the role of macrophages in various autoimmune diseases, we searched the literature on macrophages with the PubMed database. Search terms are as follows: macrophages, polarization, signaling pathways, noncoding RNA, inflammation, autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, lupus nephritis, Sjogren’s syndrome, Guillain-Barré syndrome, and multiple sclerosis. In the present study, we summarize the role of macrophage polarization in common autoimmune diseases. In addition, we also summarize the features and recent advances with a particular focus on the immunotherapeutic potential of macrophage polarization in autoimmune diseases and the potentially effective therapeutic targets. |
| format | Article |
| id | doaj-art-ea2341f0e47f4abe880b5c6e20e2fc0d |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ea2341f0e47f4abe880b5c6e20e2fc0d2025-08-20T03:24:52ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/8821610Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune DiseasesYuan Peng0Mengxian Zhou1Hong Yang2Ruyi Qu3Yan Qiu4Jiawen Hao5Hongsheng Bi6Dadong Guo7Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineQingdao Traditional Chinese Medicine Hospital (Qingdao Hiser Hospital)Shandong University of Traditional Chinese MedicineThe Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases; Shandong Academy of Eye Disease Prevention and TherapyShandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases; Shandong Academy of Eye Disease Prevention and TherapyMacrophages are innate immune cells in the organism and can be found in almost tissues and organs. They are highly plastic and heterogeneous cells and can participate in the immune response, thereby playing a crucial role in maintaining the immune homeostasis of the body. It is well known that undifferentiated macrophages can polarize into classically activated macrophages (M1 macrophages) and alternatively activated macrophages (M2 macrophages) under different microenvironmental conditions. The directions of macrophage polarization can be regulated by a series of factors, including interferon, lipopolysaccharide, interleukin, and noncoding RNAs. To elucidate the role of macrophages in various autoimmune diseases, we searched the literature on macrophages with the PubMed database. Search terms are as follows: macrophages, polarization, signaling pathways, noncoding RNA, inflammation, autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, lupus nephritis, Sjogren’s syndrome, Guillain-Barré syndrome, and multiple sclerosis. In the present study, we summarize the role of macrophage polarization in common autoimmune diseases. In addition, we also summarize the features and recent advances with a particular focus on the immunotherapeutic potential of macrophage polarization in autoimmune diseases and the potentially effective therapeutic targets.http://dx.doi.org/10.1155/2023/8821610 |
| spellingShingle | Yuan Peng Mengxian Zhou Hong Yang Ruyi Qu Yan Qiu Jiawen Hao Hongsheng Bi Dadong Guo Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases Mediators of Inflammation |
| title | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
| title_full | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
| title_fullStr | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
| title_full_unstemmed | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
| title_short | Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases |
| title_sort | regulatory mechanism of m1 m2 macrophage polarization in the development of autoimmune diseases |
| url | http://dx.doi.org/10.1155/2023/8821610 |
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