Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial
Background: Traumatic brain injury (TBI) can result in different complications. Posttraumatic headache (PTH) is a disabling complication of TBI. We investigated the therapeutic effect of memantine on patients with PTH. Materials and Methods: This randomized and double-blinded clinical trial was perf...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-03-01
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| Series: | Journal of Research in Medical Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jrms.jrms_542_24 |
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| author | Fariborz Khorvash Elham Bani Rasool Soltani Majid Rezvani Mohammad Saadatnia Noushin Maktoobian Mohsen Kheradmand |
| author_facet | Fariborz Khorvash Elham Bani Rasool Soltani Majid Rezvani Mohammad Saadatnia Noushin Maktoobian Mohsen Kheradmand |
| author_sort | Fariborz Khorvash |
| collection | DOAJ |
| description | Background:
Traumatic brain injury (TBI) can result in different complications. Posttraumatic headache (PTH) is a disabling complication of TBI. We investigated the therapeutic effect of memantine on patients with PTH.
Materials and Methods:
This randomized and double-blinded clinical trial was performed in 2020 in a hospital on 90 patients with head trauma. Patients were divided into two groups. The active group received 5 mg memantine tablet for 2 weeks followed by 10 mg tablet daily for up to 6 months. The control arm received identical placebo tablets. Patients were evaluated at 3 months and 6 months. Headache severity was measured with a Visual Analog Scale for Pain. Headache frequency (per week) and duration were also recorded.
Results:
After 3 months, the patients in the memantine group had significantly lower headache severity (P = 001) and frequency (P = 0.008) in comparison to baseline of the study. However, in the placebo group, there was only significant reduction in the headache duration (P = 0.001), and there was no significant reduction in headache intensity and frequency. After 6 months, there was a significant reduction in headache intensity and duration in both groups (P < 0.05), but only in the memantine group, headache frequency was significantly reduced (P < 0.001). Finally, patients in the memantine group had less headache intensity, frequency, and duration after 6 months of taking memantin than the placebo group.(P < 0.05 for all).
Conclusion:
The administration of memantine for 6 months could significantly lower the severity, duration, and frequency of PTHs. |
| format | Article |
| id | doaj-art-ea22861673dd41b3adf46d905f5a98f3 |
| institution | OA Journals |
| issn | 1735-1995 1735-7136 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj-art-ea22861673dd41b3adf46d905f5a98f32025-08-20T02:11:55ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362025-03-01301151510.4103/jrms.jrms_542_24Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trialFariborz KhorvashElham BaniRasool SoltaniMajid RezvaniMohammad SaadatniaNoushin MaktoobianMohsen KheradmandBackground: Traumatic brain injury (TBI) can result in different complications. Posttraumatic headache (PTH) is a disabling complication of TBI. We investigated the therapeutic effect of memantine on patients with PTH. Materials and Methods: This randomized and double-blinded clinical trial was performed in 2020 in a hospital on 90 patients with head trauma. Patients were divided into two groups. The active group received 5 mg memantine tablet for 2 weeks followed by 10 mg tablet daily for up to 6 months. The control arm received identical placebo tablets. Patients were evaluated at 3 months and 6 months. Headache severity was measured with a Visual Analog Scale for Pain. Headache frequency (per week) and duration were also recorded. Results: After 3 months, the patients in the memantine group had significantly lower headache severity (P = 001) and frequency (P = 0.008) in comparison to baseline of the study. However, in the placebo group, there was only significant reduction in the headache duration (P = 0.001), and there was no significant reduction in headache intensity and frequency. After 6 months, there was a significant reduction in headache intensity and duration in both groups (P < 0.05), but only in the memantine group, headache frequency was significantly reduced (P < 0.001). Finally, patients in the memantine group had less headache intensity, frequency, and duration after 6 months of taking memantin than the placebo group.(P < 0.05 for all). Conclusion: The administration of memantine for 6 months could significantly lower the severity, duration, and frequency of PTHs.https://journals.lww.com/10.4103/jrms.jrms_542_24durationfrequencyheadachememantineseveritytraumatic brain injury |
| spellingShingle | Fariborz Khorvash Elham Bani Rasool Soltani Majid Rezvani Mohammad Saadatnia Noushin Maktoobian Mohsen Kheradmand Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial Journal of Research in Medical Sciences duration frequency headache memantine severity traumatic brain injury |
| title | Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial |
| title_full | Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial |
| title_fullStr | Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial |
| title_full_unstemmed | Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial |
| title_short | Therapeutic effect of memantine on patients with posttraumatic headache: A randomized double-blinded clinical trial |
| title_sort | therapeutic effect of memantine on patients with posttraumatic headache a randomized double blinded clinical trial |
| topic | duration frequency headache memantine severity traumatic brain injury |
| url | https://journals.lww.com/10.4103/jrms.jrms_542_24 |
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