SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer

SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer

Over 60% of breast cancer cases are diagnosed with estrogen-receptor (ER) positive. Tamoxifen (TAM), a commonly employed medication for ER-positive breast cancer, often yields suboptimal therapeutic outcomes due to the emergence of TAM resistance, leading to the recurrence and a poor prognosis. The...

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Bibliographic Details
Main Authors: Xudong Li, Jingjing Ge, Mengdi Wan, Tongtong Feng, Xiaoqian Li, Haibo Zhang, Zhangyan Wang, Yongsheng Gao, Meiting Chen, Fei Pan
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
ER-positive breast cancer
Tamoxifen resistance
SLC31A1
CPT1A
FAO
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000041
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