A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches
Diabetic sarcopenia is a common complication of diabetes, substantially impacting patients’ quality of life and prognosis. Its pathogenesis is closely related to energy metabolism, with mitochondria—often referred to as the cellular “powerhouse”—playing a central role in this process. This review fo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-07-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605251355996 |
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| _version_ | 1849702958615232512 |
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| author | Zhilin Xie Yuanhao Li Xiaoliu Li Jing Zhang |
| author_facet | Zhilin Xie Yuanhao Li Xiaoliu Li Jing Zhang |
| author_sort | Zhilin Xie |
| collection | DOAJ |
| description | Diabetic sarcopenia is a common complication of diabetes, substantially impacting patients’ quality of life and prognosis. Its pathogenesis is closely related to energy metabolism, with mitochondria—often referred to as the cellular “powerhouse”—playing a central role in this process. This review focuses on the role of mitochondrial dysfunction in diabetic sarcopenia, emphasizing mechanisms such as energy metabolism imbalance, oxidative stress–induced damage, and abnormalities in mitochondrial biogenesis and dynamics. Additionally, we discussed current research on diagnostic and therapeutic strategies targeting mitochondrial dysfunction. This narrative review aims to provide a theoretical foundation for a deeper understanding of the pathophysiology of diabetic sarcopenia and the development of novel therapeutic approaches. |
| format | Article |
| id | doaj-art-ea214cfbd4604097a971d0c634c0fdb7 |
| institution | DOAJ |
| issn | 1473-2300 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj-art-ea214cfbd4604097a971d0c634c0fdb72025-08-20T03:17:27ZengSAGE PublishingJournal of International Medical Research1473-23002025-07-015310.1177/03000605251355996A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approachesZhilin XieYuanhao LiXiaoliu LiJing ZhangDiabetic sarcopenia is a common complication of diabetes, substantially impacting patients’ quality of life and prognosis. Its pathogenesis is closely related to energy metabolism, with mitochondria—often referred to as the cellular “powerhouse”—playing a central role in this process. This review focuses on the role of mitochondrial dysfunction in diabetic sarcopenia, emphasizing mechanisms such as energy metabolism imbalance, oxidative stress–induced damage, and abnormalities in mitochondrial biogenesis and dynamics. Additionally, we discussed current research on diagnostic and therapeutic strategies targeting mitochondrial dysfunction. This narrative review aims to provide a theoretical foundation for a deeper understanding of the pathophysiology of diabetic sarcopenia and the development of novel therapeutic approaches.https://doi.org/10.1177/03000605251355996 |
| spellingShingle | Zhilin Xie Yuanhao Li Xiaoliu Li Jing Zhang A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches Journal of International Medical Research |
| title | A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches |
| title_full | A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches |
| title_fullStr | A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches |
| title_full_unstemmed | A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches |
| title_short | A review of mitochondrial dysfunction in diabetic sarcopenia: Mechanisms, diagnosis, and treatment approaches |
| title_sort | review of mitochondrial dysfunction in diabetic sarcopenia mechanisms diagnosis and treatment approaches |
| url | https://doi.org/10.1177/03000605251355996 |
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